discontinuation


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discontinuation

The act of concluding participation, before completing all protocol-required elements, in a trial by an enrolled subject. Subject discontinuation does not necessarily imply exclusion of the subject’s data from analysis.

Categories of discontinuation
• Dropout—Discontinuation of a trial by a subject or the discontinued subject him- or herself.
• Investigator initiated discontinuation (e.g., for cause).
• Loss to follow-up—Cessation of participation without notice or action by the subject.
• Sponsor initiated.
References in periodicals archive ?
Clinicians with admitting privileges to the Hospital were notified by mail of discontinuation of the BT test as approved by a multidisciplinary Hospital Laboratory Committee in January 1999.
Three outcome variables were used in this analysis: current use of a modern contraceptive method, method mix and contraceptive discontinuation resulting in unmet need.
5] Our findings were contrast with the study conducted and reported by Mahdy and El-Zeinyin Egypt where discontinuation rate was higher in first year (28%).
For patients who experience severe discontinuation symptoms with a minor dosage reduction, venlafaxine can be tapered over 10 months with approximately 1% dosage reduction every 3 days.
Women in the postabortion group had a higher rate of earlier method discontinuation in the first 12 months than did women in the postpartum group (hazard ratio, 1.
The researchers cautioned clinicians and patients contemplating a drug holiday after 5 years of treatment to "be aware that short-term monitoring to detect individuals at higher risk who might resume bisphosphonate therapy, or initiate another therapy, may not add to risk prediction over and above age and BMD measured at the time of discontinuation.
This general decline is indicative of some level of discontinuation among users (19,20).
Barnes called poor warfarin persistence for stroke prevention in patients with atrial fibrillation "a major problem," citing the 38% probability of discontinuation within 1 year in his study of patients started on the drug for this indication at seven anticoagulation clinics participating in the Michigan Anticoagulation Quality Improvement Initiative.
TSB was measured for each neonate at admission, on discontinuation of phototherapy, and 24 hours and 48 hours later.
Agency for Health Care Policy and Research (AHCPR) initiated 2 projects in 1999 to answer the question of EBM for weaning and discontinuation from mechanical ventilation.