discontinuation


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discontinuation

The act of concluding participation, before completing all protocol-required elements, in a trial by an enrolled subject. Subject discontinuation does not necessarily imply exclusion of the subject’s data from analysis.

Categories of discontinuation
• Dropout—Discontinuation of a trial by a subject or the discontinued subject him- or herself.
• Investigator initiated discontinuation (e.g., for cause).
• Loss to follow-up—Cessation of participation without notice or action by the subject.
• Sponsor initiated.
References in periodicals archive ?
Caption: "Our results support the use of denosumab in second line after bisphosphonate therapy to restrain the BMD loss at its discontinuation," Dr.
Discontinuation of oral antivirals in chronic hepatitis B: a systematic review.
Distribution and investigation between respondents' religious affiliation and attitude towards discontinuation of FGC revealed that higher proportion of men who were Muslim (43%) than men who belong to traditional faith (41%) were not favourably disposed to the continuation of FGC while 23.5% of men who were Christian supported discontinuation of FGC
To prevent the high-turnover bone loss associated with denosumab discontinuation, an antiresorptive treatment was proposed.
Early Implanon discontinuation is defined as discontinuation at less than 2.5 years after insertion of Implanon [8, 9].
The aim of this study was to investigate the change in corneal toricity and associated refractive astigmatism after discontinuation of long-term ortho-k lens wear and to compare it with children wearing spectacles from a historical control group.
The trend analysis post intervention discontinuation shows that both hospitals experienced a very negligible monthly increase in early CFR.
In contrast to the available recommendation to discontinue metformin, there were no guidelines on the management plan upon metformin discontinuation. Thus, diabetes management following metformin discontinuation was at the discretion of the physician-in-charge.
A concurrent nested mixed-methods approach was used to capture the experiences of patients with chronic pain and their physicians after OxyContin discontinuation. This study was reviewed and approved bythe Office ofResearch Ethics at the University of Waterloo and the Health Sciences Research Ethics Board at Western University.
The discontinuation of the device did not come as a surprise, since the company has been gradually phasing it out from its physical stores since early September, according to (http://www.macrumors.com/2016/10/04/apple-discontinues-apple-tv-3/) MacRumors.
Although findings from this large observational study from Finland suggest that women stopping hormone therapy (HT) experienced elevations in cardiac and stroke mortality within the first year after discontinuation, these associations are not likely to be causal and contradict those of the Women's Health Initiative, the largest randomized trial of HT, which found no elevated risks after discontinuation of HT.