dirty necrosis

dirty necrosis (large intestine)

A term of art referring to the microscopic appearance typically seen in the centre of a focus of metastatic colorectal adenocarcinoma, which is characterised by a proliferation of complex, obviously malignant glands, cylindrical to ovoid in shape, with abundant eosinophilic nuclear debris.
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Dirty necrosis and/or columnar cells with basal nuclei could also be of help.
The evaluated histologic parameters included the presence of dirty necrosis, columnar cell morphology with basally located nuclei, microacinar architecture, lymphovascular involvement, mucin production, and presence of prominent nucleoli (easily discernible at x20 objective magnification).
Of the 6 histologic parameters, the presence of dirty necrosis, seen in 5 (100%) of 5 cases of CRCa and 2 (18%) of 11 cases of PCa, and the presence of columnar cells with basal nuclei, seen in 5 (100%) of 5 cases of CRCa and 1 (9%) of 11 cases of PCa, were the most useful parameters.