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dirithromycin/di·rith·ro·my·cin/ (di-rith″ro-mi´sin) a macrolide antibiotic used in the treatment of bacterial infections of the respiratory tract, streptococcal pharyngitis, and skin and soft tissue infections; administered orally.
indications It is used to treat infections of the respiratory tract caused by Moraxella catarrhalis, Streptococcus spp. (S. pneumoniae, S. agalactiae, S. viridans), Legionella pneumophila, Mycoplasma pneumoniae, S. pyogenes, Staphylococcus aureus, Bordetella pertussis, and Propionibacterium acnes.
contraindications Factors that prohibit its use are bacteremia and known hypersensitivity to erythromycin or to dirithromycin or any other macrolide.
adverse effects Pseudomembranous colitis is a life-threatening effect of this drug. Other adverse effects are GI disorders, flatulence, abnormal stools, anorexia, constipation, increased platelet count, increased eosinophils, cough, dyspnea, pruritus, and urticaria. Common side effects are abdominal pain, nausea, diarrhea, vomiting, dyspepsia, headache, dizziness, and insomnia.