pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin
, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones.
(12) Dirithromycin is the second generation of semisynthetic macrolide derived from erythromycin with a 14-membered lactone ring.
(15,16) For the enhancement of low bioavailability data and requirement of safer formulations dirithromycin was incorporated into polymeric nanoparticles in this study.
Other report  showed the preparation of dirithromycin (9-N-11-O-oxazine derivative) by condensation of 9(S)-erythromycylamine with 2-(2-methoxy-ethoxy)acetaldehyde.
Preston et al., "Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin," Antimicrobial Agents and Chemotherapy, vol.
In an attempt to overcome limitation of Erythromycin like narrow spectrum and some pharmacokinetic drawbacks, number of semi synthetic macrolides have been produced namely, roxithromycin, clarithromycin, azithromycin, spiramycin, dirithromycin
Susceptibility of penicillin-susceptible and resistant pneumococci to dirithromycin
compared with susceptibilities to erythromycin, azithromycin, clarithromycin, roxithromycin, and clindamycin.
He was diagnosed with malaria and bronchopneumania and treated orally with halofantrine, dirithromycin
, and acetylcysteine.
Other macrolide antibiotics include dirithromycin
and troleandomycin, which are not used extensively in children, and tacrolimus, which is used in solid organ transplantation as an immunosuppressant.
A multicentre study comparing the safety and efficacy of dirithromycin
with erythromycin in the treatment of bronchitis.
The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin
, and roxithromycin.