dirithromycin


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dirithromycin

 [di-rith″ro-mi´sin]
a macrolideantibiotic used in treatment of bacterial infections of the respiratory tract, streptococcal pharyngitis, and skin and soft tissue infections; administered orally.

dirithromycin

/di·rith·ro·my·cin/ (di-rith″ro-mi´sin) a macrolide antibiotic used in the treatment of bacterial infections of the respiratory tract, streptococcal pharyngitis, and skin and soft tissue infections; administered orally.

dirithromycin

an antiinfective.
indications It is used to treat infections of the respiratory tract caused by Moraxella catarrhalis, Streptococcus spp. (S. pneumoniae, S. agalactiae, S. viridans), Legionella pneumophila, Mycoplasma pneumoniae, S. pyogenes, Staphylococcus aureus, Bordetella pertussis, and Propionibacterium acnes.
contraindications Factors that prohibit its use are bacteremia and known hypersensitivity to erythromycin or to dirithromycin or any other macrolide.
adverse effects Pseudomembranous colitis is a life-threatening effect of this drug. Other adverse effects are GI disorders, flatulence, abnormal stools, anorexia, constipation, increased platelet count, increased eosinophils, cough, dyspnea, pruritus, and urticaria. Common side effects are abdominal pain, nausea, diarrhea, vomiting, dyspepsia, headache, dizziness, and insomnia.

dirithromycin

Dynabac® Infectious disease A macrolide antibiotic similar to erythromycin, clarithromycin, azithromycin

dirithromycin

(dīrith´rōmī´sin),
n brand name: Dynabac;
drug class: macrolide antibiotic;
action: binds to 50S ribosomal subunits of susceptible bacteria to inhibit bacterial growth;
uses: treatment of secondary bacterial infection of acute bronchitis, community-acquired pneumonia, streptococcal pharyngitis, and uncomplicated skin and skin structure infections.
References in periodicals archive ?
Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin.
In an attempt to overcome limitation of Erythromycin like narrow spectrum and some pharmacokinetic drawbacks, number of semi synthetic macrolides have been produced namely, roxithromycin, clarithromycin, azithromycin, spiramycin, dirithromycin etc.
Susceptibility of penicillin-susceptible and resistant pneumococci to dirithromycin compared with susceptibilities to erythromycin, azithromycin, clarithromycin, roxithromycin, and clindamycin.
He was diagnosed with malaria and bronchopneumania and treated orally with halofantrine, dirithromycin, and acetylcysteine.
The patient in this report also received dirithromycin, a macrolide antibiotic that may have exacerbated the cardiac effects of mefloquine and halofantrine [1].
Other macrolide antibiotics include dirithromycin and troleandomycin, which are not used extensively in children, and tacrolimus, which is used in solid organ transplantation as an immunosuppressant.
02 mg/L) the liver to inac- 7 (1 mg/mi) tive metabolites Clarithromycin 65- 70 Metabolized to active metabolite (14-OH) clar- ithromycin Undergoes exten- sive first pass metabolism Dirithromycin 15-30 Non-enzymatic conversion to erythromycy- lamine Erythromycin 70-74 Hepatic; demethylation Bioavailability Macrolide Elimination (%) Azithromycin 4.
A multicentre study comparing the safety and efficacy of dirithromycin with erythromycin in the treatment of bronchitis.
The new macrolide antibiotics: azithromycin, clarithromycin, dirithromycin, and roxithromycin.
Lilly's dirithromycin is marketed under various trade names in several countries, including Austria, Belgium, the Philippines and Spain.
Dynabac, whose generic name is dirithromycin, is useful in treating certain bacteria that cause lower-respiratory-tract infections, pharyngitis, tonsillitis, and skin and skin structure infections.
Lilly already markets dirithromycin under various trade names in several countries, including Austria, Belgium, the Philippines and Spain.