directed differentiation

directed differentiation

The use of growth factors to stimulate stem cells to specialize into specific adult cells.
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References in periodicals archive ?
Citation: Samira Musah et al., Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
Directed differentiation efficiency and functionality are increased with 'clean slate' AlphaSTEM naive cells.
These cells do not yet have DNA methylation marks that have already committed the cells to certain developmental decisions, but directed differentiation efficiency and functionality are increased with 'clean state' AlphaSTEM naive cells.
Directed differentiation of stem cells into MNs holds a great promise for the in vitro modeling of neurodegenerative diseases and cellular replacement therapies [23].
However, as of today, directed differentiation of CECs has not been clearly identified and the ability to clearly detect a definitive CEC clone derived from pluripotent or stem cells sources is still insufficient.
In 2006 the International Society for Cellular Therapy (ISCT) proposed basic criteria for determining MSCs, namely, adhesive fibroblast-like cells that are CD105, CD73, and CD90 positive and CD45, CD34, CD14, or CD11b, CD19, or CD79a and HLA-DR negative, capable of directed differentiation into adipogenic, osteogenic, and chondrogenic lineages.
More directed differentiation of ESCs to the neuronal lineage occurred upon addition of 0.5 [micro]M alltrans-retinoic acid (RA, Millipore, Billerica, MA, USA) to the culture for an additional 4 days.
TEHRAN (FNA)- Age-related macular degeneration could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, new research suggests.
Novel strategies such as using transgenic expression of the genetically engineered human recombinant DNases in proliferating and directed differentiation resisting stem cells are being developed to inhibit or prevent the iatrogenic cancerogenesis (6).
One hypothesis is that through directed differentiation, pluripotent stem cells can be differentiated into functional insulin secreting beta cells.