directed differentiation

directed differentiation

The use of growth factors to stimulate stem cells to specialize into specific adult cells.
References in periodicals archive ?
Directed differentiation efficiency and functionality are increased with 'clean slate' AlphaSTEM naive cells.
These cells do not yet have DNA methylation marks that have already committed the cells to certain developmental decisions, but directed differentiation efficiency and functionality are increased with 'clean state' AlphaSTEM naive cells.
Pluripotent stem cells have two important properties that make them extremely promising for biomedical cell therapy products: they have an effectively unlimited capacity for self-renewal and thus can be manufactured at large industrial scale; and they have the potential to be differentiated into any tissue in the body, provided the appropriate "recipe" for directed differentiation is figured out.
This will set the stage for examining whether state-specific energy metabolism programs regulate the fate plasticity of adult NSCs, as following their directed differentiation towards distinct lineages in vivo (Aim I).
More directed differentiation of ESCs to the neuronal lineage occurred upon addition of 0.
TEHRAN (FNA)- Age-related macular degeneration could be treated by transplanting photoreceptors produced by the directed differentiation of stem cells, new research suggests.
Novel strategies such as using transgenic expression of the genetically engineered human recombinant DNases in proliferating and directed differentiation resisting stem cells are being developed to inhibit or prevent the iatrogenic cancerogenesis (6).
The goal of Nishant's project during his freshman and sophomore year was to identify genes that mark different stages in the process of directed differentiation.
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.
Singapore, Mar 1, 2012 - (ACN Newswire) - A*STAR scientists have for the first time, identified that precise regulation of polyamine levels is critical for embryonic stem cell (ESC) self-renewal - the ability of ESCs to divide indefinitely - and directed differentiation.
Specific topics include isolation of adult mouse stem keratinocytes using magnetic cell sorting, growth and stratification of epithelial cells in minimal culture conditions, establishment of spontaneously immortalized keratinocyte lines from wild-type and mutant mice, directed differentiation of human embryonic stem cells to epidermal progenitors, expression and analysis of exogenous proteins in epidermal sells, and gene expression profiling of mouse epidermal keratinocytes.
Having learnt some lessons from SCNT (cloning), we need to be very cautious in generating stem cells by directed differentiation (IPS) or de-differentiation for cell therapy to treat diseases.