direct agglutination


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Related to direct agglutination: indirect agglutination

direct agglutination

The formation of an insoluble network of antigens and their antibodies, when the antigen is mixed with specific antiserum. Direct agglutination reactions are used, for example, in typing blood or in assessing the presence of antibodies against microorganisms.
See also: agglutination
References in periodicals archive ?
Direct agglutination test and other assays for measuring antibodies to Toxoplasma gondii.J.
First, as evidenced by the CAP TMRC 2012 survey, 80.2% of transfusion services do not routinely perform an antiglobulin test for weak D on patients who tested negative with anti-D by direct agglutination. As a result, most persons who have inherited a serological weak D phenotype will be typed as Rh positive when presenting as a blood donor, in compliance with Standards, but typed as Rh negative when presenting as a patient.
Nongovermnent healthcare providers and Government of Southern Sudan--administered healthcare facilities thus had to confirm suspected kala-azar by direct agglutination test before they could receive a supply of the first-line treatment--sodium stibogluconate--from WHO through Pharmaciens sans Frontieres.
Most partial D red blood cells will demonstrate direct agglutination in routine serologic tests and thus type as Rh(D) positive.
From January 2000 to February 2006, a total of 3,645 patients suspected of having kala-azar were screened at Amudat Health Centre by using the direct agglutination test or rK39 antigen-based dipsticks (6); 2,088 patients with confirmed disease were treated with daily intramuscular injections of sodium stibogluconate or meglumine antimonite, 20 mg/kg bodyweight, for 30 days.

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