direct Coombs test

di·rect Coombs test

(kūmz), Avoid the incorrect forms Coomb and Coomb's.
a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia: the patient's erythrocytes are washed with saline to remove serum and unattached antibody protein, then incubated with Coombs anti-human globulin (usually serum from a rabbit or goat previously immunized with human globulin); after incubation, the system is centrifuged and examined for agglutination, which indicates the presence of so-called incomplete or univalent antibodies on the surface of the erythrocytes.

direct Coombs test

See Antiglobulin test.

di·rect Coombs test

(dĭr-ekt kūmz test)
Assessment to detect sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.

Coombs,

Robin R.A., English veterinarian and immunologist, 1921–.
Coombs serum - serum from a rabbit or other animal previously immunized with purified human globulin to prepare antibodies directed against IgG and complement. Synonym(s): antihuman globulin
Coombs test - a test for antibodies, the so-called antihuman globulin test, using either the direct or indirect Coombs tests. Synonym(s): antiglobulin test
direct Coombs test - a test for detecting sensitized erythrocytes in erythroblastosis fetalis and in cases of acquired immune hemolytic anemia.
Gell and Coombs reaction - see under Gell
indirect Coombs test - a test routinely performed in cross-matching blood or in the investigation of transfusion reaction.
References in periodicals archive ?
The minor blood groups of the mother and baby tested to investigate the etiology of hyperbilirubinemia and positive direct Coombs test were as follows: mother: C(+) c(+) E(-) e(+) Kell (-), baby: C(+) c(+) E(+) e(+) Kell(-).
These tests showed positive antinuclear antibody (1: 1000 granular pattern), anti-Ro (SSA) antibody (2+), anti-La (SSB) antibody (3+), Ro-52 (3+), and direct Coombs test (immunoglobulin G) (4+).
Arthralgias, lymphopenia, raised globulins and markedly raised ESR brought our mind towards some autoimmune process, but antinuclear antibody (ANA) and direct Coombs test were negative.
Provision of equipment and reagents for the production of blood groups and phenotyping, RAI and direct Coombs test.
She was diagnosed with as autoimmune hemolytic anemia (ATHA) based on a high reticulocyte count, positive direct Coombs test, hemoglobinuria, and low haptoglobin level, and received the conventional treatment of prednisone (2 mg/kg in divided doses) and blood transfusions.
2] concluded that 'post-phototherapy neonatal bilirubin rebound to clinically significant levels may occur, especially in cases of prematurity, direct Coombs test positivity, and those treated [greater than or equal to] 72 hours'.
Her blood type was AB-Rh positive; the direct Coombs test was negative.
The patient was negative for hepatitis A, B, and C virus antibodies and antimitochondrial antibodies and had a negative direct Coombs test result.
Diagnosis of CAHA is based on a positive direct Coombs test in the presence of cold agglutinins.
Moreover, results of a direct Coombs test were negative, although a routine peripheral blood smear revealed the presence of "bite cells.
Laboratory findings revelead that the direct Coombs test was positive in 9 (30.
The lactate dehydrogenase (LDH) level was elevated to 1014U/L and direct coombs test (DAT) was repeated and again negative.