Albrecht-Schmitt, "Metal-controlled assembly of uranyl diphosphonates
toward the design of functional uranyl nanotubules," Inorganic Chemistry, vol.
inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo .
Medical therapy has very limited role in the treatment of calcinosis cutis but drugs like corticosteroids, probenecid, colchicine, sodium etidronate, diphosphonates
, diltiazem, and magnesium and aluminium antacids can be used in order to relieve the symptoms9,10.
Innovations that have emerged from such studies include preventive fluoridation and the development of the diphosphonates
used in the treatment of Paget's disease.
Medical management using diphosphonates
with an anti-osteoclastic effect reduce the recurrence rate to 4.2%.
But since soft tissue retention of diphosphonates
is known to be as high as 30% of whole-body retention, it seems appropriate to measure soft tissue retention and net bone uptake.
The bisphosphonates (at that time called diphosphonates
), characterized by P-CP motifs, were among these classes [1-4].
(14-18) Similarly, diphosphonates
have been used to inhibit calcification of the osteoid matrix but have not demonstrated a clear advantage.
The effects of metallic ions and diphosphonates
on inhibition of pericardial bioprosthetic tissue calcification and associated alkaline phosphatase activity.
Medical subject headings and search terms included "bisphosphonates," "diphosphonates
," "glucocorticoids," "steroids," and "osteoporosis." We examined bibliographies of selected citations and review articles to obtain additional references.