diphosphonates

diphosphonates

A group of drugs that interfere with crystal formation and are used to relieve the symptoms of PAGET'S DISEASE of bone.
References in periodicals archive ?
Albrecht-Schmitt, "Metal-controlled assembly of uranyl diphosphonates toward the design of functional uranyl nanotubules," Inorganic Chemistry, vol.
Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo .
Medical therapy has very limited role in the treatment of calcinosis cutis but drugs like corticosteroids, probenecid, colchicine, sodium etidronate, diphosphonates, diltiazem, and magnesium and aluminium antacids can be used in order to relieve the symptoms9,10.
Innovations that have emerged from such studies include preventive fluoridation and the development of the diphosphonates used in the treatment of Paget's disease.
Medical management using diphosphonates with an anti-osteoclastic effect reduce the recurrence rate to 4.2%[8].
But since soft tissue retention of diphosphonates is known to be as high as 30% of whole-body retention, it seems appropriate to measure soft tissue retention and net bone uptake.
The bisphosphonates (at that time called diphosphonates), characterized by P-CP motifs, were among these classes [1-4].
(14-18) Similarly, diphosphonates have been used to inhibit calcification of the osteoid matrix but have not demonstrated a clear advantage.
Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calciC c ation in vivo.
Recent studies, such as those by Sandler (22) and Hommeyer (23), have proved that administering etidronate or pamidronate (both being diphosphonates used in treating Paget's disease) compete with methylene diphosphate (MDP/technetium-99m MDP) due its structural similarity.
The effects of metallic ions and diphosphonates on inhibition of pericardial bioprosthetic tissue calcification and associated alkaline phosphatase activity.
Medical subject headings and search terms included "bisphosphonates," "diphosphonates," "glucocorticoids," "steroids," and "osteoporosis." We examined bibliographies of selected citations and review articles to obtain additional references.

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