diphosphonates

A group of drugs that interfere with crystal formation and are used to relieve the symptoms of PAGET'S DISEASE of bone.

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Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo .

Local Administration of Bisphosphonate-soaked Hydroxyapatite for the Treatment of Osteonecrosis of the Femoral Head in Rabbit

Medical therapy has very limited role in the treatment of calcinosis cutis but drugs like corticosteroids, probenecid, colchicine, sodium etidronate, diphosphonates, diltiazem, and magnesium and aluminium antacids can be used in order to relieve the symptoms9,10.

UNIQUE CASE OF DYSTROPHIC TYPE CALCINOSIS CUTIS (SECONDARY TO TRAUMA)

Innovations that have emerged from such studies include preventive fluoridation and the development of the diphosphonates used in the treatment of Paget's disease.

Study of an assessment of the fate of calcium hydroxy apatite block with cortico cancellous bone graft used in communited fractures of long bone of lower limb

Medical management using diphosphonates with an anti-osteoclastic effect reduce the recurrence rate to 4.

Pathologic fracture of a giant cell tumour of the patella

14-18) Similarly, diphosphonates have been used to inhibit calcification of the osteoid matrix but have not demonstrated a clear advantage.

Incidence of heterotopic ossification and effects of various prophylactic methods after hip resurfacing

Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calciC c ation in vivo.

Controversia en relacion con el uso de bifosfonatos en pacientes con enfermedad renal

Recent studies, such as those by Sandler (22) and Hommeyer (23), have proved that administering etidronate or pamidronate (both being diphosphonates used in treating Paget's disease) compete with methylene diphosphate (MDP/technetium-99m MDP) due its structural similarity.

Interacciones medicamentosas con radiofarmaceuticos

The effects of metallic ions and diphosphonates on inhibition of pericardial bioprosthetic tissue calcification and associated alkaline phosphatase activity.

Prevention of calcification with TPEN in pericardial bioprosthetic heart valve material / Biyoprostetik kalp kapagi materyalinde kalsifikasyonun TPEN ile onlenmesi

Uptake mechanisms of the diphosphonates and gallium are different, and each study provides complementary information about different aspects of a disease process.

Nuclear medicine of the painful joint replacement

2] Another in vitro study, however, demonstrated that the diphosphonates found in some antitartar dentifrices have a negative effect on remineralization, which might suggest a potential for hypersensitivity.

Effects of tartar-control dentifrice on tooth sensitivity: a pilot study

Diphosphonates that inhibit mineralization are characterized by poor gastric absorption and gastroesophageal irritation, (12,13) and often are poorly tolerated by patients.

Prevention of heterotopic ossification at the elbow following trauma using radiation therapy