However, bradycardia, heart block, and hypotension are potential risks related to the use of diphenylhydantoin
, as well as valproateinduced hepatotoxicity.
25 mg/kg, (100% anticonvulsant on electroshock-induced seizures) was ineffective on inhibiting nantenine-induced seizures.
Ophthalmoplegia resulting from diphenylhydantoin
and primidone intoxication.
fatal hepatic necrosis: a review of literature and report of a case treated exchange transfusion.
Control of her seizures was achieved with intravenous diphenylhydantoin
administration at a dose of 1000 mg/day.
Studies comparing tumors observed at the same sites after early postnatal and chronic adult exposures in a single protocol were available for six chemicals that do not act through a mutagenic mode of action [amitrole, dichlorodiphenyltrichloroethane (DDT), dieldrin, ethylene thiourea (ETU), diphenylhydantoin
(DPH), polybrominated biphenyls (PBB); Table 5].
metabolism, blood levels and toxicity.
The role of inflammation in the pathogenesis of gingival enlargement during the administration of diphenylhydantoin
sodium to cats.
Possibility of teratogenic exposure with diazepam (9), diphenylhydantoin
(3), genetic factors such as trisomy 18 (7), single gene defects in blastogenesis and mutations in homeobox genes such as HLXB9 (3) have been suggested.
a) The chemicals classified as mutagenic were benzidine, benzo(a)pyrene, DEN, safrole, and vinyl chloride; the chemicals classified as not mutagenic were amitrole, diphenylhydantoin
, ethylene thiourea, and polybrominated biphenyls.
In utero exposure to the anticonvulsant diphenylhydantoin
has been associated with a broad spectrum of abnormalities, including orofacial clefts, nail and digital hypoplasia, growth abnormalities, and mental deficiency (Fedrick 1973; Monson et al.
A method for shifting from oral to intramuscular diphenylhydantoin