diphenoxylate


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Related to diphenoxylate: Loperamide, diphenoxylate hydrochloride

diphenoxylate

 [di″fen-ok´sĭ-lāt]
an agent derived from meperidine, used as the hydrochloride salt for its antiperistaltic action in management of diarrhea.

diphenoxylate

/di·phen·ox·y·late/ (di″fen-ok´sĭ-lāt) an antiperistaltic derived from meperidine; the hydrochloride salt is used as an antidiarrheal.

diphenoxylate

(dī′fĭ-nŏk′sĭ-lāt′)
n.
An oral drug derived from meperidine, C30H32N2O2, that counteracts peristalsis and is used in its hydrochloride form primarily in combination with atropine to treat diarrhea.

diphenoxylate

A drug related to PETHIDINE and with a codeine-like action on the bowel. It is used to treat diarrhoea. It is sold, mixed with a little ATROPINE, under the brand name of Lomotil.

diphenoxylate

a derivative of meperidine with little analgesic effect, but used as the hydrochloride for the management of diarrhea.
References in periodicals archive ?
Synthetic agents, diphenoxylate and loperamide, come in convenient dosage forms and provide prompt symptomatic but temporary relief.
Diphenoxylate and atropine combination has not been associated with impaired fertility or fetal harm in animals and humans; infrequent dosing is probably compatible with nursing.
The fourth group received Diphenoxylate (5 mg/kg body wt.
Antiperistaltic agents, such as diphenoxylate (Lomotil[R]) and loperamide (Imodium[R]), are used for treatment of diarrhea; however, they should not be used in patients with high fever or with blood in the stool; these drugs should be discontinued if symptoms persist more than 48 hours.
Diarrhoea can usually be controlled with synthetic opiates such as loperamide or diphenoxylate.
During the first half of 2000 the company received an ANDA for diphenoxylate with atropine tablets, the generic equivalent to Lomotil, a product used for diarrhea/colon spasms.
Antimotility agents such as loperamide (Imodium) and diphenoxylate with atropine (Lomotil) act to slow intraluminal flow of intestinal contents by increasing segmenting contractions in the intestine.
This patient repeatedly requested diphenoxylate and was later hospitalized after taking an overdose of this drug in an attempt to commit suicide.
for diphenoxylate hydrochloride with atropine tablets (one of Mallinckrodt's major generic drug products), and it maintains a copromotion with SmithKline Beecham PLC to detail that company's Dexedrine product for ADHD.
The company's first entry into the generics marketplace is diphenoxylate hydrochloride and atropine sulfate tablets USP.