DPP4

(redirected from dipeptidylpeptidase IV)

DPP4

A gene on chromosome 2q24.3 that encodes dipeptidyl-peptidase 4, a ubiquitous, membrane-bound enzyme with roles in nutrition, metabolism, the endocrine system, immune regulation (for instance, it is essential for T-cell receptor (TCR)-mediated T-cell activation), bone marrow mobilisation, apoptosis, cell adhesion and tumourigenesis.
References in periodicals archive ?
Thimme, "Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26)," The Journal of Immunology, vol.
Dipeptidylpeptidase IV converts intact B-type natriuretic peptide into its des-SerPro form.
Comparative studies of the sugar chains of aminopeptidase N and dipeptidylpeptidase IV purified from rat kidney brush-border membrane.
Sialoforms of dipeptidylpeptidase IV from rat kidney and liver.
Dipeptidylpeptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV [Review].
1-{[(3-Hydroxy-1-adamantyl)amino]acetyl}-2-cyano(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidylpeptidase IV inhibitor with antihyperglycemic properties.