dipeptidyl peptidase


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di·pep·ti·dyl pep·ti·dase

(dī-pep'ti-dil pep'ti-dās),
A hydrolase occurring in a number of forms: dipeptidyl peptidase I, dipeptidyl transferase, cleaving dipeptides from the amino end of polypeptides; dipeptidyl peptidase II, with properties similar to those of I, has a different specificity and acts preferably on tripeptides; dipeptidyl peptidase III acts on longer peptides.

di·pep·ti·dyl pep·ti·dase

(dī-pep'ti-dil pep'ti-dās)
A hydrolase occurring in two forms: dipeptidyl peptidase I, dipeptidyl transferase, cleaving dipeptides from the amino end of polypeptides; dipeptidyl peptidase II, with properties similar to those of form I, has a different specificity.
References in periodicals archive ?
Other prescribed treatments after the initial diagnosis included sulfonylureas (7%), insulin (6%), dipeptidyl peptidase 4 inhibitors (6%), sodium-glucose cotransporter 2 inhibitors (1.5%) and a variety of combination treatments typically metformin plus sufonylureas (5%).
Effects on lipid profile of dipeptidyl peptidase 4 inhibitors, pioglitazone, acarbose, and sulfonylureas: Meta-analysis of placebo controlled trials.
BXCL701 is an orally-available systemic innate-immune activator that inhibits dipeptidyl peptidase 8/9 and FAP developed by BTI.
Association between use of sodium-glucose cotransporter 2 inhibitors, glucagon-like peptide 1 agonists, and dipeptidyl peptidase 4 inhibitors with all-cause mortality in patients with type 2 diabetes: a systematic review and meta-analysis.
Dipeptidyl peptidase 4-inhibitor (DPP4i) could prevent the inactivation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, thus raising plasma concentrations of the intact, active forms of these peptides and thereby improving islet function by increasing a-cell and [sz]-cell sensitivity to glucose.[1] DPP4i has been used widely for blood glucose control.
The researchers studied three types of diabetes treatment: sodium-glucose cotransporter 2 (SGLT-2) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors.
Federici et al., "Effects of dipeptidyl peptidase 4 inhibitors and sodium-glucose linked cotransporter-2 inhibitors on cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis," International Journal of Cardiology, vol.
([6]) They are very much short acting as they are rapidly degraded by an enzyme dipeptidyl peptidase (DPP)-4 which exists in various cell types including vascular, intestinal, and renal cells, ([7]) and its inhibition by DPP-4 inhibitors prolongs the action of them.
The team from Kolkata's CSIR-Indian Institute of Chemical Biology, Republic of Korea's Institute for Basic Science (IBS), Kolkata's Vidyasagar College and the Institute of Postgraduate Medical Education and Research (IPGMER) here has in a recent study answered a long standing question as to why diabetics have more amount of an enzyme called dipeptidyl peptidase 4 or DPP4 in their blood.
Because of the host restriction conferred by the binding of the MERS-CoV spike protein to its receptor, dipeptidyl peptidase 4 (DPP4), small animal models that are routinely used to conduct infectious disease research are not naturally susceptible to MERS-CoV infection.
Abbreviations CAD: Coronary artery disease CRP: C-reactive protein CX3CL1: Fractalkine CX3CR1: Fractalkine receptor DPP-4: Dipeptidyl peptidase 4 IL: Interleukin LPS: Lipopolysaccharide MCP-1: Monocyte chemoattractant protein-1 PBMCs: Peripheral blood mononuclear cells T2DM: Type 2 diabetes TNF-[alpha]: Tumor necrosis factor alpha.
There is no doubt that major cardiovascular events (MACE), death, and heart failure are indeed robust clinical endpoints; however, some of the results such as the potential heart failure signal for the dipeptidyl peptidase 4 (DPP-4) inhibitor saxagliptin in SAVORTIMI 53 or the pronounced cardiovascular benefit of the sodium-dependent glucose transporter 2 (SGLT-2) inhibitors empagliflozin and canagliflozin were rather surprising.