dioxygenases


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dioxygenases

enzymes which incorporate both atoms of O2 into one substrate. Less common than mono-oxygenases. Important example is the 15-15′-dioxygenase enzyme in the small intestine which cleaves plant carotenoids containing provitamin A activity, such as β-carotene, into retinal. This enzyme is absent from felines, such as the cat, and is the reason cats are dependent on animal sources of vitamin A.
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Among the topics are a computational model for byproducts of wastewater treatment, the numerical modeling and visualization of traffic of dispersion particles in the apparatus, metal control on structure and function of Ni(Fe) dioxygenases included in the methionine salvage pathway: the role of Tyr-fragment and macrostructures in the mechanism of catalysis on model systems, the control of fluidic jet repulsion in the electrospinning process, and modifying urea-formaldehyde resin with collagen biopolymers.
However, ultra-high performance liquid chromatography-tandem mass spectrometry analysis showed that ascorbic acid can markedly enhance the efficiency of iterative 5mC oxidation by directly enhancing the catalytic activity of TET dioxygenases, thereby regulating the dynamics of DNA methylation in vitro [22].
Molecular pathways: targeting IDO1 and other tryptophan dioxygenases for cancer immunotherapy," Clinical Cancer Research, vol.
Functionally, they are a family of dioxygenases (TET 1/2/3), which convert 5-methylcytosine to 5-hydroxymethyl-cytosine.
When the levels of α-KG are abnormally low, another class of enzymes called dioxygenases don't function properly, resulting in a host of additional disturbances," Dr.
Once created, 5-methylcytosine can be further modified by a group of methylcytosine dioxygenases (Ten Eleven Translocation dioxygenases: TET1, TET2, and TET3) to 5'-hydroxymethylcytosine, a presumed short-lived intermediary that may lead to demethylation of cytosine.
First, IDH1/2 (isocitrate dehydrogenase 1/2) mutations are gain-of-function mutations; wide type IDH1/2 converts isocitrate to [alpha]-ketoglutarate, and the mutant IDH1/2 converts [alpha]-ketoglutarate ([alpha]KG) to 2-hydroglutarate (2HG), which inhibits TET2 as well as [alpha]KG-dependent dioxygenases and histone demethylases (Fig.
Detection of Meta-and Ortho-Cleavage Dioxygenases in Bacteria phenol-degraders.
5-mC can be further modified to 5-hydroxymethyl Cytosine (5-hmC) by the TET family of methyl-cytosine dioxygenases.
Influence of chlorine substituent on rates of oxidation of chlorinated biphenyls by the biphenyl dioxygenases of burkholderia sp.
Their topics include copper dioxygenases, energy conversion and conservation by cytochrome oxidases, the structure and reactivity of copper-oxygen species revealed by competitive oxygen-18 isotope effects, chemical reactivity in copper active-oxygen complexes, supramolecular copper dioxygen chemistry, and organic synthetic methods using copper oxygen chemistry.