Ah receptor

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Ah receptor

A receptor that is detectable in many tissues and organs which binds various environmental pollutants, including polycyclic aromatic hydrocarbons, hetercyclic amines and polychlorinated aromatic compounds (e.g., dioxins, dibenzofurans and biphenyls), and mediates the well-known carcinogenic effects of these agents. Once bound via a helix-loop-helix motif and activated, the Ah receptor-ligand complex is transported to the nucleus where it binds to specific DNA sequences and variously turns genes on or off.
References in periodicals archive ?
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.
Cross-talk in the female rat mammary gland: influence of aryl hydrocarbon receptor on estrogen receptor signaling
Matsumoto et al., "Modulation of oestrogen receptor signalling by association with the activated dioxin receptor," Nature, vol.
Aryl hydrocarbon receptor (AhR) modulates cockroach allergen-induced immune responses through active TGF[beta]1 release
* Many compounds that can dock in a cell's dioxin receptor may prove benign--and at times even therapeutic--new studies indicated (155: 156).
SCIENCE NEWS of the Year
Most people, however, know it by its more ominous name: the dioxin receptor.
Redefining Dioxins
Aryl hydrocarbon or dioxin receptor: biologic and toxic responses.
Aryl hydrocarbon receptor deficiency enhances insulin sensitivity and reduces PPAR-[alpha] pathway activity in mice
They argue that something is a dioxin only if it can turn on a cell's dioxin receptor, also called an aryl hydrocarbon (Ah) receptor.
Pesticides the newest `dioxins'
Immortalized mouse mammary fibroblasts lacking dioxin receptor have impaired tumorigenicity in a subcutaneous mouse xenograft model.
Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs
Once that binding occurs, the dioxin receptor complex "sends out mixed signals that alter the expression of a multitude of different hormones or hormone receptors," she says.
Beyond estrogens: why unmasking hormone-mimicking pollutants proves so challenging
Therefore, we measured dioxin-like activity in serum using the dioxin receptor (DR, or AhR)-driven Chemical-Activated LUciferase eXpression (DR-CALUX) in cultured H4IIE cells, as described in detail elsewhere (Koppen et al.
Serum dioxin-like activity is associated with reproductive parameters in young men from the general Flemish population
A study now appears to confirm what these scientists had come to suspect: The "dioxin receptor" harbors a split personality.
Did evolution really anticipate dioxin?
Only very small amounts of single ortho halobiphenyls can be found in commercial mixtures, and these mixtures are quite ineffective in eliciting effects associated with binding by the dioxin receptor.
Bioremediation monitoring
Silbergeld, who is also an adjunct scientist to the Environmental Defense Fund, says there is no evidence that the dioxin receptor needs a specific accumulation of TCDD before it binds.
Clarifying dioxin's cellular invasion
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