suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3.
Anti-cancer of dioscin
on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
Summary: Two new alkaloidal steroid glycosides; solanoid A and B (1 and 2), along with two known alkaloidal steroid glycosides; solamargine (3) and khasianine (4) a known steroidal saponin; dioscin
(5), a benzoylated steroid, carpesterol (6) methyl caffeate (7), ferulic acid (8) and oleic acid (9) were isolated from the methanolic extract of Solanum surattense.
The fresh rhizome contains various saponins such as Huangjiangsu A, zingiberensis new saponin, deltonin, dioscin
, and gracillin (Table 1) .
The plant contains saponins; these are glycosides, such as diosgenin, dioscin
and dioscorin, and are used in the manufacture of steroids.
Amongst these compounds, diosgenin, a well-known steroidal sapogenin which originated by the hydrolysis of the saponin dioscin
(Figure 1), which can be obtained from several plants, namely, from Dioscorea, Trigonella, Costus [5-7], and Smilax species , is classically used in traditional medicine against a variety of medical conditions.
Standards (purity 98%) of protodioscin, dioscin
, gracillin, diosgenin, protogracillin, and polyphyllin V were purchased from Phytomarker Ltd., Tianjin.
Qi et al., "Dioscin
attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70," Pharmacological Research, vol.
is a natural steroid saponin that presents in various plants.
It is synthesized through UV irradiation of dioscin
, which is extracted from Chinese yams or soybeans.
Diosgenin, a steroid sapogenin of the saponin dioscin
, can undergo oxidation to produce a progesterone-like structure that has been used to synthesize human sex hormones and to treat conditions that are regulated by these hormones.
Yin et al., "Dioscin
reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway," International Immunopharmacology, vol.