Identification and quantification by LC-MS and LC-ICP-MS of arsenic species in urine of rats chronically exposed to dimethylarsinic acid
The urinary excretion of arsenic metabolites after a single oral administration of dimethylarsinic acid
 Nonstandard abbreviations: MMA, methylarsonic acid; DMA, dimethylarsinic acid
; AB, arsenobetaine; HGAAS, hydride generation-atomic absorption spectrometry; ICPMS, inductively coupled plasma mass spectrometry; CRM, Certified Reference Material; NIES, National Institute for Environmental Studies; ICP-AES, inductively coupled plasma atomic emission spectrometry; RSD, relative standard deviation; MIP-MS, microwave-induced plasma mass spectrometry; ETAAS, electrothermal vaporization atomic absorption spectrometry; INAA, instrumental neutron activation analysis; and ID, isotope dilution.
Abbreviations: B12, vitamin [B.sub.12]; BHMT, betaine homocysteine methyltransferase; DMA, dimethylarsinic acid
; InAs, inorganic As; MMA, monomethylarsonic acid.
causes apoptosis in HL-60 cells via interaction with glutathione.
Estimated Change (95% Percent CI) No Seafood in No Seafood 24-hour in 30-day (c) All Study Participants Total Arsenic (a) 14.2 (11.3, 17.6 (10.3, 17.1) 25.3) Dimethylarsinic Acid
13.4 (10.5, 14.5 (8.2, (b) 16.4) 21.2) Age Category 6 to 11 years Total Arsenic (a) 16.1 (11.6, 17.1 (8.9, 20.7) 26.0) Dimethylarsinic Acid
14.7 (10.5, 14.1 (5.5, (b) 19.0) 23.3) 12 to 17 years Total Arsenic (a) 12.8 (9.2, 16.6 (9.0, 16.5) 24.7) Dimethylarsinic Acid
12.5 (8.7, 13.5 (5.8, (b) 16.4) 21.8) Abbreviations: CI, confidence interval All models include daily rice consumption as per 1/4 cup cooked rice (continuous) and predict [log.sub.10]-transformed urinary arsenic concentration (all parameter estimates are exponentiated).
Arsenite [As(III)], arsenate [As(V)], monomethylarsonic acid (MMAA), and dimethylarsinic acid
(DMAA) are widely present in the natural environment [25-29].(1) The toxicity varies dramatically with different chemical forms of arsenic; the median lethal dose ([LD.sub.50]) values in rats for some arsenic compounds [29-31] are (in mg/kg): potassium arsenite 14, calcium arsenate 20, MMAA 700-1800, DMAA 700-2600, and arsenobetaine >10 000.
Metabolic status was based on urinary concentrations of methylarsonic acid (MMA) and dimethylarsinic acid
(DMA), and multivariable logistic regression was used to estimate associations.
As species calibrators of monomethylarsonic acid (MMA), dimethylarsinic acid
(DMA), and arsenobetaine (AsB) were provided by the Commission of the European Union, DGXII, Measurements and Testing Programme.
One finding was that uCr was the strongest predictor of As methylation; participants with higher uCr concentrations had a higher percentage of total urinary As as dimethylarsinic acid
(DMA) compared to those with lower uCr.
The main As species in the serum of these patients are dimethylarsinic acid
(DMA) and arsenobetaine (AsB), respectively carrying 15.2% (0.71 [+ or -] 1.05 [micro]g/L) and 76.2% (3.56 [+ or -] 4.27 [micro]g/L) of total As.
2011), we cited their earlier results concerning urinary dimethylarsinic acid
(DMA) and creatinine concentrations, noting that in 2005 they reported a strong correlation between urinary creatinine and the percentage of DMA (DMA%) (Gamble et al.