Oral exposure of dimethylarsinic acid
, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-Oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis.
Chromatographic separation and identification of products from the reaction of dimethylarsinic acid
with hydrogen sulfide.
Gene damage induced in human alveolar type II (L-132) cells by exposure to dimethylarsinic acid
Rice grown in the United States has been shown to contain higher amounts of total arsenic and a lower proportion of inorganic arsenic [and higher organic arsenic in the form of dimethylarsinic acid
(DMA)] than rice from other countries (Meharg et al.
2011), we cited their earlier results concerning urinary dimethylarsinic acid
(DMA) and creatinine concentrations, noting that in 2005 they reported a strong correlation between urinary creatinine and the percentage of DMA (DMA%) (Gamble et al.
The main As species in the serum of these patients are dimethylarsinic acid
(DMA) and arsenobetaine (AsB), respectively carrying 15.
Arsenic (As) occurs as monomethylarsonic acid (MMA) and dimethylarsinic acid
(DMA) in humans, and the methylation pattern demonstrates large interindividual differences.
01) and positively associated with the percentage of dimethylarsinic acid
([beta] = 0.
In vitro biotransformation of dimethylarsinic acid
and trimethylarsine oxide by anaerobic microflora of mouse cecum analyzed by HPLC-ICP-MS and HPLC-ESI-MS.
Metabolic conversion of inorganic As (iAs) to dimethylarsinic acid
(DMA) reduces toxicity and facilitates urinary As (uAs) elimination, but the intermediate metabolite monomethylarsonic (MMA) may have increased cytoxic and genotoxic effects.
Key WORDS: arsenic, Bangladesh, cobalamin, creatinine, dimethylarsinic acid
, folate, homocysteine, monomethylarsonic acid, one-carbon metabolism.
METHODS: We used hydride generation-atomic absorption spectrometry (HGAAS) to determine iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid