dimethyl sulfoxide


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to dimethyl sulfoxide: Dimethyl sulfate, Dimethyl sulfide

DMSO

 
dimethyl sulfoxide, an industrial solvent that has the ability to penetrate plant and animal tissues and to preserve living cells during freezing. It has been used investigationally as an agent to increase the penetrability of other substances and as a topical analgesic and antiinflammatory. It has been approved by the U.S. Food and Drug Administration in a 50 per cent solution for direct instillation into the bladder for the treatment of interstitial cystitis. A 90 per cent solution, which has been approved only for veterinary use, is believed by some to be beneficial in the treatment of muscle sprains and strains, arthritis, spinal cord injuries, and the aftereffects of stroke when it is applied externally and absorbed by the skin. Claims that it is effective for treating these disorders in humans have not been validated by research studies. It has been shown to produce some short-term side effects.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

di·meth·yl sul·fox·ide (DMSO),

(dī-meth'il sŭl-foks'īd),
A penetrating solvent, enhancing absorption of therapeutic agents from the skin; an industrial solvent that has been proposed as an effective analgesic and antiinflammatory agent in arthritis and bursitis.
Farlex Partner Medical Dictionary © Farlex 2012

di·meth·yl sul·fox·ide

(DMSO) (dī-meth'il sŭl-foks'īd)
A potent organic solvent with mild analgesic and antiinflammatory properties; used to enhance cutaneous absorption of topical agents and in the treatment of interstitial cystitis.
Synonym(s): dimethyl sulphoxide.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

dimethyl sulfoxide

Dimethyl sulfoxide, DMSO. A colorless liquid of exceptional solvent properties that readily penetrates the surface of the skin and is used as a solvent for various drugs. Under the brand name of Rimso-50 it is used as a sterile 50 per cent solution to wash out the bladder in certain cases of cystitis.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

di·meth·yl sul·fox·ide

(DMSO) (dī-meth'il sŭl-foks'īd)
A penetrating solvent, enhancing absorption of therapeutic agents from the skin; an industrial solvent proposed as a useful analgesic and antiinflammatory agent.
Synonym(s): dimethyl sulphoxide.
Medical Dictionary for the Dental Professions © Farlex 2012
Mentioned in ?
References in periodicals archive ?
Dimethyl sulfoxide Affects Human Acute Myeloid HL-60 Leukemia Cell Viability
Quercetin glucuronides inhibited 2-aminofluorene acetylation, in human acute myeloid HL-60 leukemia cells
A stimulation index (SI) for each peptide was calculated by dividing the average proliferation for a given peptide by the average proliferation of control wells containing dendritic cells, CD[4.sup.+] T cells, and dimethyl sulfoxide in the absence of peptide.
A human dendritic cell-based method to identify CD[4.sup.+] T-cell epitopes in potential protein allergens. (Mini-Monograph)
The dimethyl sulfoxide (DMSO) solution was obtained from Aldrich Chemical Company (Milwaukee, WI) and designated as lot 67-68-5.
The effect of temperature on the observed flow-induced structure in semidilute solutions of gently solubilized starches
(100 mg (Elmiron) t.i.d.) hydroxyzine HCI 10-75 mg/day, $0.18 taken at bedtime (25 mg) amitriptyline 10-150 mg/day $0.36 taken with dinner (50 mg) dimethyl sulfoxide 50 mL of 50% $6.28 ** (DMSO) solution, injected once a week tolterodine 4 mg/day $2.80 (Detrol LA) oxybutynin 5-15 mg/day $2.69 (Ditropan XL) (10 mg) celecoxib 100-200 mg/day $1.49 (Celebrex) (100 mg) rofecoxib 12.5-25 mg/day $2.52 (Vioxx) phenazopyridine 200-300 mg $2.22 t.i.d.
Drug Update: Interstitial Cystitis
U0126, SB203580, and wortmannin (Calbiochem, La Jolla, CA, USA) were dissolved in dimethyl sulfoxide (DMSO).
Phosphorylation of p53 protein in A549 human pulmonary epithelial cells exposed to asbestos fibers. (Research)
Both compounds were diluted to eight different concentrations in 750 mL/L dimethyl sulfoxide (DMSO)-250 mL/L [H.sub.2]O (75% DMSO in [H.sub.2]O).
The use of inosine 5'-monophosphate dehydrogenase (IMPDH) in the development of a new liquid homogeneous enzyme immunoassay technology
Despite decades of research and thousands of studies attesting to its health-promoting properties, dimethyl sulfoxide (DMSO) remains virtually unknown to the medical professional and the public.
The untapped healing potential of DMSO
Dimethyl sulfoxide (DMSO) and other solvents are of analytical grade and used without further purification.
Morphology and Physicochemical Performance of Water-soluble Carboxymethyl Chitosan/Polyurethane Blend Film
Intravesical administration of dimethyl sulfoxide must be done by physicians in the office.
Multimodal Treatment Appears Best for Interstitial Cystitis
PENNSAID contains diclofenac sodium, an NSAID, and also includes dimethyl sulfoxide (DMSO), a powerful penetrating agent that helps ensure that diclofenac sodium is absorbed through the skin to the site of inflammation and pain.
Horizon Pharma receives the US Patent and Trademark Office's additional notice of allowance for non-steroidal anti-inflammatory drug PENNSAID 2%

Medical browser ?
Full browser ?