The active metabolite formed by the N-demethylation of trimethadione, an oxazolidinedione type antiepileptic agent. Can be used for in vivo measurement of intracellular pH.
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Teratogenic: Drugs like thalidomide, dimethadione, cadmium, chemicals, viruses, radiation, hypothermia and hyperthermia.
They are rapidly absorbed, biotransformed in the liver to active metabolites and slowly eliminated via the renal system.[2,5,8,9] The half-life of trimethadione is 11-16 hours; its active metabolite, dimethadione, has a half-life of about 10 days.