dimercaprol


Also found in: Dictionary, Encyclopedia, Wikipedia.
Related to dimercaprol: Succimer

dimercaprol

 [di″mer-kap´rol]
a colorless, liquid chelating agent used in the treatment of heavy metal poisoning; it forms a relatively stable compound with arsenic, mercury, gold, and certain other metals, thus protecting the vital enzyme systems of the cells against the effects of the metals. It is sometimes diluted with water and used to wash the stomach, with some of the solution being left in the stomach. Side effects include tachycardia, hypertension, nausea and vomiting, severe headaches, and a sense of constriction of the chest; barbiturates are usually ordered to relieve the symptoms, which should subside within an hour. Dimercaprol has a disagreeable skunklike odor and should be handled carefully to avoid spilling. Called also British antilewisite.

di·mer·cap·rol

(dī'mĕr-kap'rol),
A chelating agent, developed as an antidote for lewisite and other arsenical poisons. It acts by competing for the metal with the essential -SH groups in the pyruvate oxidase system of the cells and forms, with arsenic, a stable, relatively nontoxic cyclic compound, the metal having a greater affinity for it than for the -SH groups of the cell proteins; also used as an antidote for antimony, bismuth, chromium, mercury, gold, and nickel.

dimercaprol

(dī′mər-kăp′rôl, -rōl)
n.
A colorless oily viscous liquid, C3H8OS2, used as an antidote for poisoning caused by lewisite, organic arsenic compounds, and heavy metals including mercury and gold. Also called British anti-lewisite.

di·mer·cap·rol

(dī'mĕr-kap'rol)
A chelating agent, developed as an antidote for lewisite and other arsenical poisons; also used as an antidote for antimony, bismuth, chromium, mercury, gold, and nickel poisoning.

dimercaprol

British Anti-Lewisite (BAL). A drug that takes up toxic metal ions from the body and can be life-saving in poisoning with lead, arsenic, gold, mercury, antimony, bismuth and thallium. The drug is on the WHO official list. It was developed during World War I in the course of a search for antidotes to poison war gases, particularly the arsenical Lewisite.

Dimercaprol (BAL)

A chemical agent used to remove excess lead from the body.
Mentioned in: Lead Poisoning
References in periodicals archive ?
Dimercaprol, also called 2,3-Dimercaptopropanol, was developed by British biochemists during World War II as an antidote for lewisite, an obsolete arsenic-based chemical warfare agent.
Reduced (not [7] (25 one-day specified) cycles) 56/M DMPS oral Reduced (not [8] (14mg/kg/day specified) for 6 days, 4 mg/kg for 5 days, and 4 mg/kg for 4 days) 52/M Dimercaprol Co decrease (by [9] (1 three-day 33%) cycle) 55/M DMPS Not specified [10] (Not specified) 75/M NAC oral + i.v.
Edetate calcium disodium forms stable chelates with a number of metals, but it is primarily used for lead overdose, either alone or in combination with dimercaprol. There are only a few reports of its use in human pregnancy, all occurring late in gestation.
La accion del dimercaprol es de caracter lipofilo; por eso, si se supera la dosis optima, es danino para el SNC.
Chelating agents are used to treat lead poisoning cases and include chemicals such as Bal (Dimercaprol), Ca[Na.sub.2]EDTA, and Succimer (Giannattasio, 1998).
* Dimercaprol is either used alone (arsenic, gold, and acute mercury) or combined with edetate calcium disodium (lead).
The boy was treated with dimercaprol (i.e., BAL) followed by calcium disodium versenate (i.e., EDTA), and his BLL decreased to 57 [micro]g/dL.
Both acute and chronic exposure is treated with chelation with dimercaprol (BAL), DMSA (succimer), d-penicillamine DMPS (CEHN, 1999; AAP, 2003).
One type contained the anthrax vaccine and the other contained phials of a drug called dimercaprol which acts as an antidote to heavy metal poisoning.
Other chelation agents include DMPS (Sodium Dimercaptopropanesulfonate) and Dimercaprol (BAL).
Control or sample (0.5 mL) was pipetted into plastic tubes, and 10 [micro]L of dimercaprol solution and 10 [micro]L of 8-hydroxyquinoline solution were added to each tube and mixed.
Chelation therapy with CaEDTA and dimercaprol (BAL) was performed.