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an antihistamine used as an antinauseant, antiemetic, and antivertigo agent, especially in prevention and treatment of motion sickness, but also in other conditions in which nausea or vertigo may be a feature, administered orally, rectally, or by intramuscular or intravenous injection.


Apo-Dimenhydrinate (CA), Arlevert (UK), Dramamine, Dramanate (CA), Gravol (CA), PMS-Dimenhydrinate (CA), Travamine (CA), TripTone

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo agent

Pregnancy risk category B


Prevents nausea and vomiting by inhibiting vestibular stimulation of chemoreceptor trigger zone and inhibiting stimulation of vomiting center in brain


Injection: 50 mg/ml

Tablets: 50 mg

Tablets (chewable): 50 mg

Indications and dosages

Prevention and treatment of nausea, vomiting, dizziness, and vertigo

Adults and children ages 12 and older: 50 to 100 mg P.O. q 4 hours (not to exceed 400 mg/day), or 50 mg I.M. or I.V. q 4 hours p.r.n.

Children ages 6 to 12: 25 to 50 mg P.O. q 6 to 8 hours (not to exceed 150 mg/day), or 1.25 mg/kg I.M. (37.5 mg/m2) q 6 hours p.r.n.

Children ages 2 to 6: 12.5 to 25 mg P.O. q 6 to 8 hours (not to exceed 75 mg/day)


• Hypersensitivity to drug or tartrazine
• Alcohol intolerance


Use cautiously in:
• angle-closure glaucoma, seizure disorders, prostatic hypertrophy
• children younger than age 2.


• For I.V. use, dilute with dextrose 5% in water or normal saline solution.
• Give each 50-mg I.V. dose over 2 minutes.

Don't administer by I.V. route to premature or low-birth-weight infants. Solution contains benzyl alcohol, which can cause fatal "gasping" syndrome.

Adverse reactions

CNS: drowsiness, dizziness, headache, paradoxical stimulation (in children)

CV: hypotension, palpitations

EENT: blurred vision, tinnitus

GI: diarrhea, constipation, dry mouth

GU: dysuria, urinary frequency

Skin: photosensitivity

Other: decreased appetite, pain at I.M. site


Drug-drug.Disopyramide, quinidine, tricyclic antidepressants: increased anticholinergic effects

MAO inhibitors: intensified and prolonged anticholinergic effects

Other CNS depressants (such as antihistamines, opioids, sedative-hypnotics): additive CNS depression

Ototoxic drugs (such as aminoglycosides, ethacrynic acid): masking of signs or symptoms of ototoxicity

Drug-diagnostic tests.Allergy skin tests: false-negative results

Drug-behaviors.Alcohol use: increased CNS depression

Patient monitoring

• Assess for lethargy and drowsiness.
• Monitor for dizziness, nausea, and vomiting (possible indicators of drug toxicity).

Patient teaching

• To prevent motion sickness, advise patient to take drug 30 minutes before traveling and to repeat dose before meals and at bedtime.
• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Caution patient to avoid alcohol and sedative-hypnotics during therapy.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.


/di·men·hy·dri·nate/ (di″men-hi´drĭ-nāt) an antihistamine used as an antiemetic, particularly in the treatment of motion sickness.


A drug composed of two chemicals, diphenhydramine and 8-chlorotheophylline, used to prevent motion sickness.


an antiemetic.
indications It is prescribed in the treatment of nausea and motion sickness.
contraindications Asthma or known hypersensitivity to this drug prohibits its use. It is not given to newborns or lactating mothers.
adverse effects Among the more serious adverse reactions are skin rash, hypersensitivity reactions, and tachycardia. Drowsiness and dry mouth are common.


n brand names: Calm-X, Dimentabs, Dinate, Dramamine;
drug class: antihistamine, H1 receptor antagonist;
actions: acts on blood vessels and gastrointestinal and respiratory systems by competing with histamine for H1 receptor sites; decreases allergic response by blocking histamine;
uses: motion sickness, nausea, vomiting.


an antihistamine used as an antinauseant and antiemetic.
References in periodicals archive ?
Marill et al compared lorazepam 2 mg IV with dimenhydrinate 50 mg IV and found that lorazepam provided better control of symptoms.
Dimenhydrinate 50 mg proved to be more effective than meclizine 50 mg.
In addition to the finding that meclizine 50 mg was less effective than dimenhydrinate 50 mg,(2) meclizine has been found to be less effective than transdermal scopolamine.
Intravenous lorazepam versus dimenhydrinate for treatment of vertigo in the emergency department: A randomized clinical trial.
Effects of dimenhydrinate on gastric tachyarrhythmia and symptoms of vection-induced motion sickness.
Food and Drug Administration (FDA) of its Abbreviated New Drug Application (ANDA) for Dimenhydrinate Injection, USP.
According to the February 1, 2003 issue of the American Journal of Health-System Pharmacists, Dimenhydrinate Injection shortages began in 1998 and manufacturing of the product was completely discontinued approximately two years later for reasons other than safety or efficacy.
By bringing Dimenhydrinate Injection back to the market, APP is providing an important therapeutic option for nausea and vomiting resulting from various causes including surgical procedures," said Patrick Soon-Shiong, M.
The return of Dimenhydrinate Injection to the market provides physicians an economical and effective treatment option for those patients who bear the burden of this serious and bothersome symptom.
The US National Institute of Drug Abuse has also warned of the possible abuse of over-the-counter (OCT) medicines such as cough suppressants, sleep aids, antihistamines and dimenhydrinates (in Gravol C or Dramamine) for their C psychoactive effects.