Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.


an antihistamine used as an antinauseant, antiemetic, and antivertigo agent, especially in prevention and treatment of motion sickness, but also in other conditions in which nausea or vertigo may be a feature, administered orally, rectally, or by intramuscular or intravenous injection.


Apo-Dimenhydrinate (CA), Arlevert (UK), Dramamine, Dramanate (CA), Gravol (CA), PMS-Dimenhydrinate (CA), Travamine (CA), TripTone

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo agent

Pregnancy risk category B


Prevents nausea and vomiting by inhibiting vestibular stimulation of chemoreceptor trigger zone and inhibiting stimulation of vomiting center in brain


Injection: 50 mg/ml

Tablets: 50 mg

Tablets (chewable): 50 mg

Indications and dosages

Prevention and treatment of nausea, vomiting, dizziness, and vertigo

Adults and children ages 12 and older: 50 to 100 mg P.O. q 4 hours (not to exceed 400 mg/day), or 50 mg I.M. or I.V. q 4 hours p.r.n.

Children ages 6 to 12: 25 to 50 mg P.O. q 6 to 8 hours (not to exceed 150 mg/day), or 1.25 mg/kg I.M. (37.5 mg/m2) q 6 hours p.r.n.

Children ages 2 to 6: 12.5 to 25 mg P.O. q 6 to 8 hours (not to exceed 75 mg/day)


• Hypersensitivity to drug or tartrazine

• Alcohol intolerance


Use cautiously in:

• angle-closure glaucoma, seizure disorders, prostatic hypertrophy

• children younger than age 2.


• For I.V. use, dilute with dextrose 5% in water or normal saline solution.

• Give each 50-mg I.V. dose over 2 minutes.

Don't administer by I.V. route to premature or low-birth-weight infants. Solution contains benzyl alcohol, which can cause fatal "gasping" syndrome.

Adverse reactions

CNS: drowsiness, dizziness, headache, paradoxical stimulation (in children)

CV: hypotension, palpitations

EENT: blurred vision, tinnitus

GI: diarrhea, constipation, dry mouth

GU: dysuria, urinary frequency

Skin: photosensitivity

Other: decreased appetite, pain at I.M. site


Drug-drug. Disopyramide, quinidine, tricyclic antidepressants: increased anticholinergic effects

MAO inhibitors: intensified and prolonged anticholinergic effects

Other CNS depressants (such as antihistamines, opioids, sedative-hypnotics): additive CNS depression

Ototoxic drugs (such as aminoglycosides, ethacrynic acid): masking of signs or symptoms of ototoxicity

Drug-diagnostic tests. Allergy skin tests: false-negative results

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Assess for lethargy and drowsiness.

• Monitor for dizziness, nausea, and vomiting (possible indicators of drug toxicity).

Patient teaching

• To prevent motion sickness, advise patient to take drug 30 minutes before traveling and to repeat dose before meals and at bedtime.

• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Caution patient to avoid alcohol and sedative-hypnotics during therapy.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.


A drug composed of two chemicals, diphenhydramine and 8-chlorotheophylline, used to prevent motion sickness.
References in periodicals archive ?
Scholtz, "Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cinnarizine and dimenhydrinate: A double-blind, randomized, parallel-group clinical study," Clinical Therapeutics, vol.
Bussi, "Fixed combination of cinnarizine and dimenhydrinate in the prophylactic therapy of vestibular migraine: an observational study," Neurological Sciences, vol.
Dimenhydrinate in children with infectious gastroenteritis: a prospective, RCT.
Allegra, "Intramuscular droperidol versus intramuscular dimenhydrinate for the treatment of acute peripheral vertigo in the emergency department: a randomized clinical trial," Academic Emergency Medicine, vol.
* The sedation consists of oral dimenhydrinate (Dramamine) 50 mg and IV midazolam 2 mg and IV metoclopramide 10 mg preoperatively in the holding area.
Diphenhydramine and dimenhydrinate poisoning: An evidence-based consensus guideline for out-of-hospital management.
Over-the-counter antihistamines, such as meclizine (Antivert, Bonine), dimenhydrinate (Dramamine), and diphenhydramine (Benadryl) are commonly used for prevention.
A comparative study with placebo and dimenhydrinate. Acta Otolaryngol.
Many other drugs have been used in treating migraines, including: acetaminophen (alone, or in combination with caffeine and butalbital, aspirin and caffeine, or isometheptene and dichloralphenazone); NSAIDs, including aspirin; chlorpromazine (Thorazine); dimenhydrinate (Dramamine); diphenhydramine (Benadryl); morphine; meperidine; intranasal butorphanol (Stadol); and corticosteroids.
Numerous other drugs have been used in treating migraines, including acetaminophen (alone, or in combination with caffeine and butalbital, aspirin and caffeine, or isometheptene and dichloralphenazone); NSAIDs, including aspirin; chlorpromazine (Thorazine); dimenhydrinate (Dramamine); diphenhydramine (Benadryl); morphine; and meperidine.
Nearly 20% of parents gave their children Dramamine (dimenhydrinate) either before they began to suffer the symptoms of motion sickness as a preventative or once the symptoms began.
George Dabakis of Springfield, Massachusetts, writes: "At the first feelings of light-headedness, rush for some generic Dramamine (dimenhydrinate) pills.