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an antihistamine used as an antinauseant, antiemetic, and antivertigo agent, especially in prevention and treatment of motion sickness, but also in other conditions in which nausea or vertigo may be a feature, administered orally, rectally, or by intramuscular or intravenous injection.


Apo-Dimenhydrinate (CA), Arlevert (UK), Dramamine, Dramanate (CA), Gravol (CA), PMS-Dimenhydrinate (CA), Travamine (CA), TripTone

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo agent

Pregnancy risk category B


Prevents nausea and vomiting by inhibiting vestibular stimulation of chemoreceptor trigger zone and inhibiting stimulation of vomiting center in brain


Injection: 50 mg/ml

Tablets: 50 mg

Tablets (chewable): 50 mg

Indications and dosages

Prevention and treatment of nausea, vomiting, dizziness, and vertigo

Adults and children ages 12 and older: 50 to 100 mg P.O. q 4 hours (not to exceed 400 mg/day), or 50 mg I.M. or I.V. q 4 hours p.r.n.

Children ages 6 to 12: 25 to 50 mg P.O. q 6 to 8 hours (not to exceed 150 mg/day), or 1.25 mg/kg I.M. (37.5 mg/m2) q 6 hours p.r.n.

Children ages 2 to 6: 12.5 to 25 mg P.O. q 6 to 8 hours (not to exceed 75 mg/day)


• Hypersensitivity to drug or tartrazine

• Alcohol intolerance


Use cautiously in:

• angle-closure glaucoma, seizure disorders, prostatic hypertrophy

• children younger than age 2.


• For I.V. use, dilute with dextrose 5% in water or normal saline solution.

• Give each 50-mg I.V. dose over 2 minutes.

Don't administer by I.V. route to premature or low-birth-weight infants. Solution contains benzyl alcohol, which can cause fatal "gasping" syndrome.

Adverse reactions

CNS: drowsiness, dizziness, headache, paradoxical stimulation (in children)

CV: hypotension, palpitations

EENT: blurred vision, tinnitus

GI: diarrhea, constipation, dry mouth

GU: dysuria, urinary frequency

Skin: photosensitivity

Other: decreased appetite, pain at I.M. site


Drug-drug. Disopyramide, quinidine, tricyclic antidepressants: increased anticholinergic effects

MAO inhibitors: intensified and prolonged anticholinergic effects

Other CNS depressants (such as antihistamines, opioids, sedative-hypnotics): additive CNS depression

Ototoxic drugs (such as aminoglycosides, ethacrynic acid): masking of signs or symptoms of ototoxicity

Drug-diagnostic tests. Allergy skin tests: false-negative results

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• Assess for lethargy and drowsiness.

• Monitor for dizziness, nausea, and vomiting (possible indicators of drug toxicity).

Patient teaching

• To prevent motion sickness, advise patient to take drug 30 minutes before traveling and to repeat dose before meals and at bedtime.

• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• Caution patient to avoid alcohol and sedative-hypnotics during therapy.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.


/di·men·hy·dri·nate/ (di″men-hi´drĭ-nāt) an antihistamine used as an antiemetic, particularly in the treatment of motion sickness.


A drug composed of two chemicals, diphenhydramine and 8-chlorotheophylline, used to prevent motion sickness.


an antiemetic.
indications It is prescribed in the treatment of nausea and motion sickness.
contraindications Asthma or known hypersensitivity to this drug prohibits its use. It is not given to newborns or lactating mothers.
adverse effects Among the more serious adverse reactions are skin rash, hypersensitivity reactions, and tachycardia. Drowsiness and dry mouth are common.


an antihistamine used as an antinauseant and antiemetic.
References in periodicals archive ?
Characteristics Treatment group, n (%) p-value Placebo (n = 100) Dimenhydrinate (n = 100) Age (months) * 32.
5-75 mg Retrospective, open-label [47] Cinnarizine + 20 mg and 40 mg Observational trial [48] dimenhydrinate Acetazolamide 500 mg Retrospective cohort study [49] Magnesium 400 mg Retrospective cohort analysis [39] Clonazepam 0.
5 mg patch * Topical Allergy operating every 3 days * Tachyarrhythmia machinery Dimenhydrinate * Dry mouth 50 mg every 4-6 hours orally Lorazepam * Drug dependence Avoid use of 0.
Randomised double-blind study to compare the activities and tolerability of Zintona and dimenhydrinate in 60 subjects with motion sickness.
Acetaminophen, caffeine, dimenhydrinate, diphenhydramine, narcotic analgesics, lidocaine, and butorphanol are compatible (i.
Daniel Mowrey cites ginger as more effective than dimenhydrinate (Dramamine) for motion and sea sickness, and many pregnant women will attest to ginger's success in conquering morning sickness.
Both doses are administered concomitantly with a tablet of an antiemetic such as a 50 mg dose of dimenhydrinate.
Some clinicians also routinely give an antiemetic or antinausea medication such as dimenhydrinate or cyclizine hydrochloride.
K is prone to motion sickness, and asks if he can take over-the-counter dimenhydrinate tablets for long car rides.
Antiemetic efficacy of prophylactic dimenhydrinate (Dramamine) vs ondansetron (Zofran): a randomized, prospective trial in patients undergoing laparoscopic cholecystectomy.
Antihistamines are inexpensive drugs available as generics; dimenhydrinate and diphenhydramine also are available as over-the-counter preparations.