These medications may be particularly useful if intravascular volume is supported with crystalloid fluids, which cause dilutional coagulopathy
This includes but is not limited to liver disease or failure, dilutional coagulopathy
from massive red blood cell transfusion, severe disseminated intravascular coagulation (DIC) refractory to prothrombinase complex concentrates or cryoprecipitate, warfarin overdose, and vitamin K deficiency.
They also reported an association between albumin transfusion and coagulopathy, although their study was not able to differentiate between dilutional coagulopathy
and an effect directly attributable to albumin itself.
In women who have severe PPH, hypofibrinogenemia may develop as a result of dilutional coagulopathy
or hypofibrinogemia in conditions such as abruptio placentae with fetal demise, acute fatty liver of pregnancy, or amniotic fluid embolism.
Beglin experienced dilutional coagulopathy
and more blood loss.
After transfusion of a large volume of conserved (not fresh) blood or large amounts of red blood cells concentrate, a dilutional coagulopathy develops, caused by a sharp drop in the platelet count and the significantly reduced activity of unstable coagulation factors in the patient's circulation [14-17].
The most common causes of coagulation disorders in the patients with massive bleeding or massive transfusions are: coagulopathy due to loss of blood type, dilutional coagulopathy, consumptive coagulopathy, hyperfibrinolysis, acidosis, hypothermia, anemia and electrolyte imbalance .
due to fluid replacement and dilution of clotting factors.