Van De Venter, "The biological activity of the histidine-containing diketopiperazines
cyclo(His-Ala) and cyclo(His-Gly)," Peptides, vol.
Polycondensation of L-Lysine Diketopiperazine
with Tartaric Acid - Evidence on the Formation of Cyclic Oligomers, Macromol.
The purity of the APM, as determined by an infrared absorption spectrophotometer assay, was > 98.7%: diketopiperazine
was < 0.3% and L-phenylalanine was < 0.5%.
This active component was isolated and identified as Cyclo (L-Leu-L-Arg) (1), a diketopiperazine derivative, possessing antibacterial and antifungal activity.
Based on the 1H, 13C NMR, and 2D (H,H COSY, HMQC, HMBC, and NOE) spectra and comparison with our recently published one , compound (1) was deduced as Cyclo (L-Leu- L-Arg), a diketopiperazine derivative (Fig.
The company said that the protected compositions contain either DA-DKP, a cyclic dipeptide diketopiperazine, which is the active ingredient of Ampion, but also extend to many other diketopiperizines.
Ampio Pharmaceuticals Inc (Nasdaq:AMPE), a developer of proprietary drugs, announced on Thursday that it has been granted a Canadian patent with broad claims directed to 'METHOD OF USING DIKETOPIPERAZINES AND COMPOSITION CONTAINING THEM'.
8 December 2011 - US Ampio Pharmaceuticals Inc (NASDAQ:AMPE), a specialist in discovery and development of new uses for approved drugs and new molecular entities (NMEs), said yesterday it had obtained a European patent with broad claims covering compositions containing DA-DKP, a cyclic dipeptide diketopiperazine
that is Ampion's active ingredient.
Under particular conditions (extreme pH, high temperature, lengthy storage times), APM may be contaminated by the diketopiperazine
(DKP) cycloaspartylphenylalanine (Butchko et al.
Ampio Pharmaceuticals Inc (Nasdaq: AMPE), a developer of proprietary drugs, on Wednesday said that it has received notification of the granting of a European patent with broad claims directed to compositions containing DA-DKP, a cyclic dipeptide diketopiperazine
which is the active ingredient of its key drug Ampion.