5,6-Dihydrouracil; a reduction product of uracil and one of the intermediates of uracil catabolism.
References in periodicals archive ?
The catabolism of C14-labeled uracil, dihydrouracil, and beta-ureidopropionic acid in rat liver slices.
The drug undergoes catabolism primarily in the liver by reduction of the pyrimidine ring by enzymatic action of dihydrouracil dehydrogenase (13).
We purchased the following compounds from Sigma: adenine, adenosine, 2-deoxyadenosine, 2-deoxyguanosine, inosine, 2-deoxyinosine, xanthine, hypoxanthine, orotic acid, uric acid, thymine, uracil, dihydrothymine, dihydrouracil, N-carbamyl-[beta]-aminoisobutyric acid, N-carbamyl-[beta]-alanine, thymidine, uridine, pseudouracil, 5-hydroxymethyluracil, and 2-deoxyuridine.
Optimal peak shapes were achieved for all analytes except for dihydrouracil and N-carbamyl-[beta]-alanine, which were characterized by broader and split peaks.
For xanthine, adenosine, 2,8-dihydroxyadenine, uracil, thymine, dihydrouracil, dihydrothymine, N-carbamyl-[beta]-amino-isobutyric acid, N-carbamyl-[beta]-alanine, uridine, and pseudouridine, the detection limit was between 1 and 10 [micro]mol/L.
Dihydrouracil was an exception; its CV was higher, at 42%.
For 2-deoxyinosine, adenosine, 2-deoxyadenosine, guanosine, 2-deoxyguanosine, succinyladenosine, orotic acid, thymine, dihydrouracil, dihydrothymine, uridine, 2-deoxyuridine, and 5-hydroxymethyluracil, sample concentrations were below the lower limits of quantification, as were the concentrations of inosine and N-carbamyl-[beta]-aminoisobutyric acid for children older than 1 year and N-carbamyl-[beta]-alanine for children older than 4 years of age.
The interference of 5,6-dihydrouridine could be eliminated by use of the transition m/z 132 [right arrow] 115 for the detection of dihydrouracil (see Fig.
Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: a potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosage.
Simple liquid chromatographic method for the determination of uracil and dihydrouracil plasma levels: a potential pretreatment predictor of 5-fluorouracil toxicity.
2) [3] to dihydrothymine (DHT) and dihydrouracil (DHU), respectively; (b) DHT is converted to N-carbamyl-[beta]-aminoisobutyric acid (N-C-[beta]-AlB) and DHU to N-carbamyl-[beta]-alanine (N-C-(3-Ala) by dihydropyrimidinase (DHP, EC 3.
Dihydrouracil dehydrogenase activity in normal, differentiating and regenerating liver and in hepatomas.

Full browser ?