dihydropyrimidine dehydrogenase


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di·hy·dro·py·rim·i·dine de·hy·dro·gen·ase

(dī-hī'drō-pī-rim'ĭ-dēn dē-hī'drō-jen-ās'), [MIM*274270]
An enzyme in pyrimidine biosynthesis that reacts 5,6-dihydrouracil with NADP+ to form uracil and NADPH; it also acts on dihydrothymine; a deficiency of this enzyme can result in hyperuracil thyminuria.
References in periodicals archive ?
Meyer et al., "Immunohistochemical analysis of thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer (cUICC II/III): correlation with histopathologic tumor regression after 5-fluorouracil-based long-term neoadjuvant chemoradiotherapy," The American Journal of Surgical Pathology, vol.
Huber, "Correlation between dihydropyrimidine dehydrogenase and efficacy and toxicity of fluoropyrimidine drugs," European Review for Medical and Pharmacological Sciences, vol.
Impacts of excision repair cross-comple menting gene 1 (ERCC1), dihydropyrimidine dehydrogenase, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer.
Muto, "Dihydropyrimidine dehydrogenase but not thymidylate synthase expression is associated with resistance to 5-fluorouracil in colorectal cancer," Hepato-Gastroenterology, vol.
A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil.
Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracil.
Quantitation of dihydropyrimidine dehydrogenase expression in tumor specimens of patients treated with 5-fluorouracil using a quantitative polymerase chain reaction assay.
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.
u1 addition, four patients with a disorder of the urea cycle and two patients with a dihydropyrimidine dehydrogenase deficiency were investigated.
In this paper, Lassmann and colleagues have evaluated the predictive value of five molecular markers associated with the metabolism of fluoropyrimidines [thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), uridine phosphorylase (UP) and uridine-cytidine kinase (UK)] and three molecular markers associated with cell proliferation and anti-apoptosis (Bcl-2-related protein, survivin and cyclin-D1).
Dihydropyrimidine dehydrogenase catalyzes the reduction of uracil and thymine to 5,6-dihydrouracil and 5,6-dihydrothymine, respectively.
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the three-step degradation of uracil to [beta]-alanine (12).

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