gene variation and severe 5-Fluorouracil toxicity: a haplotype assessment.
A role for dihydropyrimidine dehydrogenase
and thymidylate synthase in tumour sensitivity to fluorouracil.
Impacts of excision repair cross-complementing gene 1 (ERCC1), dihydropyrimidine dehydrogenase
, and epidermal growth factor receptor on the outcomes of patients with advanced gastric cancer.
Importance of dihydropyrimidine dehydrogenase
(DPD) deficiency in patients exhibiting toxicity following treatment with 5-fluorouracil.
Population study of dihydropyrimidine dehydrogenase
in cancer patients.
In patients suffering from a dihydropyrimidine dehydrogenase
deficiency, the concentrations of the pyrimidine de novo metabolites were within reference values and only highly increased concentrations of uracil were present in the urine.
In this paper, Lassmann and colleagues have evaluated the predictive value of five molecular markers associated with the metabolism of fluoropyrimidines [thymidylate synthase (TS), thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase
(DPD), uridine phosphorylase (UP) and uridine-cytidine kinase (UK)] and three molecular markers associated with cell proliferation and anti-apoptosis (Bcl-2-related protein, survivin and cyclin-D1).
catalyzes the reduction of uracil and thymine to 5,6-dihydrouracil and 5,6-dihydrothymine, respectively.
(DPD) is the initial and rate-limiting enzyme in the three-step degradation of uracil to [beta]-alanine (12).
Eniluracil, an oral dihydropyrimidine dehydrogenase
(DPD) inhibitor, is being developed to improve the tolerability and effectiveness of 5-fluorouracil (5-FU), one of the most widely used oncology drugs in the world.
(DPYD) is the initial and rate-limiting enzyme in the metabolism of the chemotherapeutic drug 5-fluorouracil (5-FU), thus affecting its pharmacokinetics, efficacy, and toxicity (1).
Catabolism of the pyrimidine bases thymine and uracil consists of three consecutive steps: (a) thymine and uracil are catabolized by dihydropyrimidine dehydrogenase
(DPD; EC 1.