The phosphoprotein with increased expression level was identified as dihydropyrimidinase-related protein 2, and 2 phosphoproteins with decreased expression level were identified as proteasome subunit alpha type-3 and beta-soluble NSF attachment protein (Table 2).
The 2 phosphoproteins with increased expression levels were identified as dihydropyrimidinase-related protein 2 and enolase 1B, retrotransposed, and the 2 phosphoproteins with decreased expression levels were identified as gamma-actin and proteasome subunit alpha type-3 (Table 2).
The expression of proteins associated with cytoskeleton and its regulations namely myosin light polypeptide 6 isoform 1 (MYL6), p27BBP protein (eIF6), dihydropyrimidinase-related protein 2
isoform 2 (DPYSL2), caldesmon (CALD1), T-complex protein 1 subunit theta isoform 1 (CCT8) and Chain A, crystal structure of AlixAIP1 (PDCD6IP) were all downregulated by MNQ.
Seven of the identified hippocampal proteins had two posttranslational modifications [albumin (ALBU), glial fibrillary acidic protein (GFAP), dihydropyrimidinase-related protein 2
(DPYL2), DPYL5, heat shock protein 74 (HSP74), creatinine kinase B-type (KCRB), and tubulin alpha-lB (TBA1B)], one had two isoforms [glyceraldehyde-3-phosphate dehydrogenase (G3P)], and one protein (DPYL3) was identified in 4 isoforms; thus, the final count for identified hippocampal proteins was 35.