DPYSL2

(redirected from dihydropyrimidinase-related protein 2)

DPYSL2

A gene on chromosome 8p22-p21 that encodes a member of the collapsin response mediator protein family, which forms homo- and heterotetramers. DPYSL2 plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration.  

Molecular pathology
DPYSL2 has been implicated in multiple neurological disorders; hyperphosphorylation of the encoded protein may play a role in the development of Alzheimer's disease.
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The phosphoprotein with increased expression level was identified as dihydropyrimidinase-related protein 2, and 2 phosphoproteins with decreased expression level were identified as proteasome subunit alpha type-3 and beta-soluble NSF attachment protein (Table 2).
The 2 phosphoproteins with increased expression levels were identified as dihydropyrimidinase-related protein 2 and enolase 1B, retrotransposed, and the 2 phosphoproteins with decreased expression levels were identified as gamma-actin and proteasome subunit alpha type-3 (Table 2).
The expression of proteins associated with cytoskeleton and its regulations namely myosin light polypeptide 6 isoform 1 (MYL6), p27BBP protein (eIF6), dihydropyrimidinase-related protein 2 isoform 2 (DPYSL2), caldesmon (CALD1), T-complex protein 1 subunit theta isoform 1 (CCT8) and Chain A, crystal structure of AlixAIP1 (PDCD6IP) were all downregulated by MNQ.
Seven of the identified hippocampal proteins had two posttranslational modifications [albumin (ALBU), glial fibrillary acidic protein (GFAP), dihydropyrimidinase-related protein 2 (DPYL2), DPYL5, heat shock protein 74 (HSP74), creatinine kinase B-type (KCRB), and tubulin alpha-lB (TBA1B)], one had two isoforms [glyceraldehyde-3-phosphate dehydrogenase (G3P)], and one protein (DPYL3) was identified in 4 isoforms; thus, the final count for identified hippocampal proteins was 35.

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