dihydrofolate reductase inhibitors

dihydrofolate reductase inhibitors

Drugs that block the action of DIHYDROFOLATE REDUCTASE. Some of the drugs that inhibit this enzyme can, as in the case of METHOTREXATE, be used as anticancer drugs. Some of them have little effect on the human enzyme but a strong effect on the dihydrofolate reductases of bacterial and other parasites. Trimetrexate (Neutrexin) is a case in point; it is active against Pneumocystis carinii .
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One group of such agents is dihydrofolate reductase inhibitors, which block the conversion of folate to its more active metabolites.
Methods: We assessed exposure to folic acid antagonists that act as dihydrofolate reductase inhibitors and to certain antiepileptic drugs in 3,870 infants with cardiovascular defects, 1,962 infants with oral clefts, and 1,100 infants with urinary tract defects, and also in 8,387 control infants with malformations, the risk of which is not reduced after vitamin supplementation.
Key classes of mechanism of action includes Interleukin inhibitors, Kinase inhibitors, cytokine targetters, TNF targetters, C5a receptor antagonists, Cathepsin inhibitors, Histone deacetylase inhibitors (HDAC) inhibitors, Janus Kinase 3(JAK-3) inhibitors, CD4 inhibitors, p38 kinase inhibitors, Dihydrofolate Reductase inhibitors, cyclooxygenase (COX) inhibitors, Chemokine receptor antagonists, Glucocorticoid antagonists, Dihydroorotate dehydrogenase(DHODH) inhibitors, and combination therapies.
In addition, a number of new drug classes such as dihydrofolate reductase inhibitors (DHFR) are under evaluation which are effective in multi drug resistant organisms.