dihydrofolate reductase inhibitors
dihydrofolate reductase inhibitorsDrugs that block the action of DIHYDROFOLATE REDUCTASE. Some of the drugs that inhibit this enzyme can, as in the case of METHOTREXATE, be used as anticancer drugs. Some of them have little effect on the human enzyme but a strong effect on the dihydrofolate reductases of bacterial and other parasites. Trimetrexate (Neutrexin) is a case in point; it is active against Pneumocystis carinii .
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005