dihydrofolate reductase


Also found in: Acronyms, Wikipedia.

di·hy·dro·fo·late re·duc·tase (DHFR),

(dī-hī'drō-fō'lāt rē-dŭk'tās), [MIM*126060]
An enzyme reversibly oxidizing tetrahydrofolate to 7,8-dihydrofolate with NADP+. A crucial enzyme in one-carbon metabolism; used as a marker of drug resistance to methotrexate.
Synonym(s): 5, 6, 7, 8-tetrahydrofolate dehydrogenase

dihydrofolate reductase

An enzyme necessary for the synthesis of the purines of DNA.
References in periodicals archive ?
hominis (2) Yes 0673A -- -- No 0817A -- -- No 0891A -- -- No 1344A -- -- No 0569D -- -- No 0776D -- -- No * PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; SSU, small subunit; COWP, Cryptosporidium oocyst wall protein; DHFR, dihydrofolate reductase gene.
Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use.
Arwati et al., "Epi-croomine and croomine from Stemona tuberosa antimalarial drug for inhibiting dihydrofolate reductase (DHFR) activity and their molecular modeling," Journal of Chemical and Pharmaceutical Research, vol.
Roper, "Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of Northern Tanzania," Antimicrobial Agents and Chemotherapy, vol.
A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance.
Plasmodium falciparum dihydrofolate reductase (PfDHFR) is one of the most important drug target for different antifolates.
Through a discretionary allocation of 1 million core-hours at the Argonne Leadership Computing Facility (ALCF), researchers at Cloud Pharmaceuticals will use Mira, a 10- petaflops IBM Blue Gene/Q supercomputer to investigate inhibitors of the dihydrofolate reductase enzyme, or DHFR, from multiple sources.
Bertino, "Dihydrofolate reductase as a therapeutic target," The FASEB Journal, vol.
In another study, novel 2,4-diaminopyrimidines bearing N,N-disubstituted aminomethyl residues at the position 5 were designed as dihydrofolate reductase (DHFR) inhibitors.
Previous studies have suggested that resistance to SP is attributed to the emergence of certain mutations that occur sequentially in dihydropteroate synthase (dhps) and dihydrofolate reductase (dhfr) genes of Plasmodium.
High-level recombinant protein expression can be achieved by amplification of the recombinant gene with a selectable marker, such as Dihydrofolate Reductase (DHFR) (21), (22).
Finally, the enzyme dihydrofolate reductase (DHFR) catalyzes the reduction of DHF back into THF (Mato et al.