Precursor to tetrahydrobiopterin, a required cofactor for a number of enzymes, including the biosynthesis of l-tyrosine; the inability to synthesize dihydrobiopterin can result in a form of malignant hyperphenylalaninemia.
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For analysis of plasma levels of biopterin, dihydrobiopterin (BH2) and tetrahydrobiopterin (BH4), we used reversed phase HPLC with electrochemical detection and fluorescence detection.
In the presence of 5-MTHF, the enzyme dihydrobiopterin reductase can reduce quininoid dihydrobiopterin to tetrahydrobiopterin (BH4) (12).
4] is oxidized to quinonoid dihydrobiopterin and is recycled to BH4 by pterin-4[alpha]-carbinolamine dehydratase (EC 4.