Dihydrobiopterin | definition of dihydrobiopterin by Medical dictionary
Precursor to tetrahydrobiopterin, a required cofactor for a number of enzymes, including the biosynthesis of l-tyrosine; the inability to synthesize dihydrobiopterin can result in a form of malignant hyperphenylalaninemia.
References in periodicals archive
For analysis of plasma levels of biopterin, dihydrobiopterin
(BH2) and tetrahydrobiopterin (BH4), we used reversed phase HPLC with electrochemical detection and fluorescence detection.
In the presence of 5-MTHF, the enzyme dihydrobiopterin
reductase can reduce quininoid dihydrobiopterin
to tetrahydrobiopterin (BH4) (12).
4] is oxidized to quinonoid dihydrobiopterin
and is recycled to BH4 by pterin-4[alpha]-carbinolamine dehydratase (EC 4.