dihydroartemisinin


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dihydroartemisinin

(dī-hī-drō'ahr-te-mis'i-nin),
An active metabolite of the antimalarial artemisinin.
References in periodicals archive ?
To treat malaria cases, health workers primarily use a combination of dihydroartemisinin and piperaquine, or DHA-PPQ.
Professor Tu Youyou is a pharmaceutical chemist who won the Nobel Prize in Physiology or Medicine in 2015 for her discovery of the drugs artemisinin and dihydroartemisinin. Her drugs have been used to treat 200 million malaria patients, saving millions of lives.
For example, their work found that frontline malaria treatments combining fast-acting dihydroartemisinin and long-acting piperaquine have failed in Cambodia because of the rapid spread of drug-resistant parasites.
Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer.
Sample results revealed that 40 out of 320 tablets met the specifications for identification of dihydroartemisinin and piperaquine phosphate.
The samples comprised tablets, suspensions, injections, and mixtures containing sulphadoxine, pyrimethamine, quinine, lumefantrine, piperaquine, sulphamethoxypyridazine, artemether, artesunate, and dihydroartemisinin APIs.
Xia et al., "Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin," Oncogene, vol.
el-Feraly, "Effects of artemisinin, dihydroartemisinin and arteether on immune responses of normal mice," International Journal of Immunopharmacology, vol.
Lai, "Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells," Life Sciences, vol.
Fleckenstein, "Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration," Malaria Journal, vol.
In Papua, Indonesia, resistance to artemisinin derivatives, artesunate and dihydroartemisinin, and semisynthetic 10-alkylamino-artemisinin derivatives, artemisone and artemiside, has also been observed in P.
Similarly, dihydroartemisinin (DHA) has been reported to arrest growth in the G1 phase of hepatoma cell lines [13] and disrupted the cell cycle at G2/M in pancreatic cancer cell lines [14].