dihydroartemisinin


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dihydroartemisinin

(dī-hī-drō'ahr-te-mis'i-nin),
An active metabolite of the antimalarial artemisinin.
References in periodicals archive ?
Plasmodium falciparum drug resistance in Madagascar: facing the spread of unusual pfdhfr and pfmdr-1 haplotypes and the decrease of dihydroartemisinin susceptibility.
Artemisinin and its derivatives, artesunate, artemether, and dihydroartemisinin, are the most rapidly acting of all antimalarials and have the fastest parasite clearance time, rapid resolution of symptoms, and an excellent safety profile.
Last year, NIAID investigators found that frontline malaria treatments containing fast-acting dihydroartemisinin and long-lasting piperaquine were losing effectiveness in Cambodia because of the concurrent spread of resistance to both drugs.
38) Nevertheless, therapy with piperaquine and dihydroartemisinin (DHA) has exhibited high effectiveness, safety, and tolerability.
Dihydroartemisinin targets VEGFR2 via the NF-KB pathway in endothelial cells to inhibit angiogenesis.
The effect of co-administration of dihydroartemisinin with vitamin E on the activities of cation ATPases in some rat tissues.
AS is a water-soluble hemisuccinate derivative of dihydroartemisinin, and also possesses anti-cancer, anti-angiogenesis and anti-inflammatory activities in human rheumatoid arthritis fibroblast-like synoviocytes (Lai HC, et al, 2014; Wang Z, et al, 2012; Wang HY, et al, 2014.
By upregulating death receptor 5 expression, ROS can enhance cellular apoptosis induced by dihydroartemisinin, a semisynthetic derivative of artemisinin [33].
There are several antimalarials targeting the blood forms of P vivax, such as chloroquine, amodiaquine, artesunate, artemether, lumefantrine, dihydroartemisinin, piperaquine, chloroquine remains the most widely used as first-line treatment for this species (2,7).
Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1.
annua contains many biologically active compounds; the most important is a sesquiterpene lactone Artemisinin and certain derivatives such as Arteether, Antemether, Artesunate and Dihydroartemisinin, this compound has been established as the most potent antimalarial drug and possesses activity against drug resistant strains of the malaria parasite (Plasmodium falciparum).