diffusion defect

diffusion defect

any impairment in the diffusion of oxygen across the alveolar-capillary membrane caused by pathological changes in any of the structures of the membrane. Specific causes may include fibrosis, granuloma, interstitial edema, and proliferation of connective tissue.
References in periodicals archive ?
The values were interpreted as follows: DLCO and DLCOHb: Normal (>80% predicted) Mild diffusion defect (65-80%), Moderate diffusion defect (45-65%) and severe diffusion defect (<45%).
There were 3 patients with restrictive ventilatory defect and no diffusion defect and 2 patients with diffusion defect and no restrictive ventilatory defect.
CUMULATIVE DOSE VS PFT: Diffusion defect and restrictive ventilatory defect occurred with least cumulative dose of 150mgs.
There were 5 patients with symptoms, no pulmonary fibrosis and diffusion defect.
Symptoms Vs Diffusion Defect Diffusion defect Normal diffusion Total Symptoms > 1 month 5 3 8 Symptoms < 1month 5 17 22 Total 10 20 30
2) patients had diffusion defect and 2 patients had restrictive pattern in spirometry.
There were 10 (33%) patients with diffusion defect in this study.
There were 7(23%) patients with diffusion defect in this study without radiological evidence of methotrexate induced pulmonary fibrosis.
3%) patients with diffusion defects without radiological abnormalities.
Home oxygen therapy is often provided to patients with IPF because of the diffusion defect they experience due to the thickened alveolar-capillary membrane caused by fibrosis of the alveolar epithelium.
The reasons for the hypoxia were universally chalked up to the usual suspects which were either chronic obstructive pulmonary disease, a diffusion defect or some vague notion that there was a sleep related hypoventilation syndrome.
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