diffuse panbronchiolitis

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Idiopathic inflammation and obstruction of bronchioles, eventually accompanied by bronchiectasis; cases originally reported are almost all from Japan.

diffuse panbronchiolitis

A severe idiopathic inflammatory condition that diffusely involves the bronchioles. It is most common in eastern Asian males and, if untreated, leads to bronchiectasis. Macrolide antibiotics—e.g., erythromycin—slows but does not halt or reverse disease progression.
Clinical findings
Chronic sinusitis, wheezing, crackles, dyspnoea, purulent sputum, hypoxia, hypercapnia, pulmonary hypertension, cor pulmonale and eventually respiratory failure.
Without erythromycin, 10-year survival is 33%; with it, 90%.
References in periodicals archive ?
Diffuse panbronchiolitis in a Hispanic man with travel history to Japan.
A report of the first three cases of diffuse panbronchiolitis in Malaysia.
Diffuse panbronchiolitis, the first case reports in Thailand.
Diffuse panbronchiolitis with histopathological confirmation among Chinese.
Diffuse panbronchiolitis in China: analysis of 45 cases.
Test and teach: number fifty-three: a rare lung disease in an Indian man: diagnosis: diffuse panbronchiolitis.
Association of HLA genes with diffuse panbronchiolitis in Chinese patients.
Fine localization of a major disease-susceptibility locus for diffuse panbronchiolitis.
Analysis of HLA antigens in patients with diffuse panbronchiolitis.
Contribution of HLA genes to genetic predisposition in diffuse panbronchiolitis.
A case of diffuse panbronchiolitis (DPB) in a patient positive for HTLV-1.
Comparative clinicopathology of obliterative bronchiolitis and diffuse panbronchiolitis.

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