differentiation therapy

differentiation therapy

Oncology A strategy used to treat malignancies with a block in the normal cell differentiation; the intent with DT is to drive malignant cells into a mature nonproliferating state of remission
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

differentiation therapy

The use of medications to make cancer cells evolve into cells no longer capable of infinite replication.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Thus the dramatic finding that ATRA therapy was successful in APL was the first example of differentiation therapy in the treatment of advanced cancer.
Differentiation therapy slows tumor growth and invasion, encouraging tumor cell death through the normal process of programmed cell death (apoptosis).
Differentiation therapy is based on the concept that immature leukemia progenitor cells can be forced to differentiate into a more mature or terminally differentiated phenotype by using differentiation-inducing agents.
Regarding these progresses, differentiation therapy is also considered for treatment of other AML patients.
This transformation, called differentiation therapy, reactivates endogenous cellular programs to elicit tumor cell maturation and the transition from cancer to normal tissue.
Lai is the differentiation therapy. He says: The disease could be prevented or cured discerning the occurrence of kinds of normal cells & cancer cells, how cancer cells differ from their normal counterparts, and what events prompts the proliferation of these abnormal cells.
One of these ways is the differentiation therapy. It is based on the induction of leukemic blasts to mature beyond the differentiation block and, thus, to restore the normal cellular phenotype.
Daniel et al., "All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia.