differentiation therapy

a cancer therapy technique in which the malignant cell is regarded as having escaped the normal controls of cell growth and differentiation. The cancer cell is regarded as pathologically arrested at an early stage of differentiation, retaining the ability to proliferate. It is treated with agents that remove this block and allow the cells to differentiate along more normal lines until they eventually lose their ability to divide and replicate.

differentiation therapy

Oncology A strategy used to treat malignancies with a block in the normal cell differentiation; the intent with DT is to drive malignant cells into a mature nonproliferating state of remission

differentiation therapy

The use of medications to make cancer cells evolve into cells no longer capable of infinite replication.

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References in periodicals archive ?

Research in WP2 will use the information gained from WP1 to develop ways of alleviating the differentiation block in AML and so deliver new agents for use in differentiation therapy.

DECIDE: Decision-making within cells and differentiation entity therapies

The concept of differentiation therapy has been viewed as a promising and revolutionary approach for the treatment of AML and other cancers for forty years ago.

These results suggest MEMAC may have useful potential for differentiation therapy of leukemic diseases.

Methanol extract of Antrodia cinnamomea mycelia induces phenotypic and functional differentiation of HL60 into monocyte-like cells via an ERK/CEBP-[beta] signaling pathway

This finding may help the designing of new protocols for T-ALL differentiation therapy in the future.

Although differentiation therapy has been widely studied in AML, there are few investigations on acute lymphoblastic leukemia, perhaps because ALL is considered a disease of differentiated lymphocytes (79).

Bryostatin-1, fenretinide and 1[alpha],25 [(OH).sub.2][D.sub.3] induce growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6)

Differentiation therapy for myelodysplastic syndrome.

A novel approach to treatment in childhood acute myeloblastic leukemia and myelodysplastic syndrome with high-dose methylprednisolone as a differentiation- and apoptosis-inducing agent of myeloid leukemic cells

Thus the dramatic finding that ATRA therapy was successful in APL was the first example of differentiation therapy in the treatment of advanced cancer.

Acute promyelocytic leukaemia, all-trans-retinoic acid and arsenic

Now in its 32nd year, the Samuel Waxman Cancer Research Foundation (SWCRF) is a unique non-profit international organization dedicated to supporting focused concept-driven research to develop targeted cancer cell-specific therapies with minimal toxicity, such as differentiation therapy.

Five New Research Programs to Receive Funding from the Samuel Waxman Cancer Research Foundation

Differentiation therapy is based on the concept that immature leukemia progenitor cells can be forced to differentiate into a more mature or terminally differentiated phenotype by using differentiation-inducing agents.

Acute promyelocytic leukemia and differentiation therapy: molecular mechanisms of differentiation, retinoic acid resistance and novel treatments/Akut promiyelositik losemi ve diferansiyasyon tedavisi: diferansiyasyonun, retinoik asit direncinin ve yeni tedavilerin molekuler mekanizmalari

Regarding these progresses, differentiation therapy is also considered for treatment of other AML patients.

3-Hydrogenkwadaphnine, a novel diterpene ester from Dendrostellera lessertii, its role in differentiation and apoptosis of KG1 cells

Now in its 32nd year, the Samuel Waxman Cancer Research Foundation (SWCRF) "Institute Without Walls" is a unique non-profit international organization dedicated to supporting focused concept-driven research to develop targeted cancer cell-specific therapies, such as differentiation therapy.

Press Conference on Status of Cancer Research Worldwide

Ansan's butyric acid derivatives employ a novel approach to cancer treatment called differentiation therapy, which causes rapidly growing, immature cells to become growth-regulated, differentiated cells.

Titan receives FDA approval to initiate Phase I clinical trial and pilot study for anticancer agents