Vitamin D3-driven signals for myeloid cell differentiation-implications for differentiation therapy
This finding may help the designing of new protocols for T-ALL differentiation therapy
in the future.
for myelodysplastic syndrome.
Thus the dramatic finding that ATRA therapy was successful in APL was the first example of differentiation therapy
in the treatment of advanced cancer.
slows tumor growth and invasion, encouraging tumor cell death through the normal process of programmed cell death (apoptosis).
is based on the concept that immature leukemia progenitor cells can be forced to differentiate into a more mature or terminally differentiated phenotype by using differentiation-inducing agents.
Regarding these progresses, differentiation therapy
is also considered for treatment of other AML patients.
This transformation, called differentiation therapy
, reactivates endogenous cellular programs to elicit tumor cell maturation and the transition from cancer to normal tissue.
Lai is the differentiation therapy
. He says: The disease could be prevented or cured discerning the occurrence of kinds of normal cells & cancer cells, how cancer cells differ from their normal counterparts, and what events prompts the proliferation of these abnormal cells.
One of these ways is the differentiation therapy
. It is based on the induction of leukemic blasts to mature beyond the differentiation block and, thus, to restore the normal cellular phenotype.
Research in WP2 will use the information gained from WP1 to develop ways of alleviating the differentiation block in AML and so deliver new agents for use in differentiation therapy
. This type of therapy aims, using only mildly toxic treatments, to induce terminal maturation of leukaemia cells and accelerate their death.
Daniel et al., "All-trans retinoic acid as a differentiation therapy
for acute promyelocytic leukemia.