differentiation therapy

differentiation therapy

Oncology A strategy used to treat malignancies with a block in the normal cell differentiation; the intent with DT is to drive malignant cells into a mature nonproliferating state of remission

differentiation therapy

The use of medications to make cancer cells evolve into cells no longer capable of infinite replication.
References in periodicals archive ?
Thus the dramatic finding that ATRA therapy was successful in APL was the first example of differentiation therapy in the treatment of advanced cancer.
Differentiation therapy slows tumor growth and invasion, encouraging tumor cell death through the normal process of programmed cell death (apoptosis).
Differentiation therapy is based on the concept that immature leukemia progenitor cells can be forced to differentiate into a more mature or terminally differentiated phenotype by using differentiation-inducing agents.
Regarding these progresses, differentiation therapy is also considered for treatment of other AML patients.
This transformation, called differentiation therapy, reactivates endogenous cellular programs to elicit tumor cell maturation and the transition from cancer to normal tissue.
Lai is the differentiation therapy. He says: The disease could be prevented or cured discerning the occurrence of kinds of normal cells & cancer cells, how cancer cells differ from their normal counterparts, and what events prompts the proliferation of these abnormal cells.
One of these ways is the differentiation therapy. It is based on the induction of leukemic blasts to mature beyond the differentiation block and, thus, to restore the normal cellular phenotype.
Research in WP2 will use the information gained from WP1 to develop ways of alleviating the differentiation block in AML and so deliver new agents for use in differentiation therapy. This type of therapy aims, using only mildly toxic treatments, to induce terminal maturation of leukaemia cells and accelerate their death.
Daniel et al., "All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia.