differentiation therapy

Oncology A strategy used to treat malignancies with a block in the normal cell differentiation; the intent with DT is to drive malignant cells into a mature nonproliferating state of remission

differentiation therapy

The use of medications to make cancer cells evolve into cells no longer capable of infinite replication.

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References in periodicals archive ?

Vitamin D3-driven signals for myeloid cell differentiation-implications for differentiation therapy. Leuk.

Methanol extract of Antrodia cinnamomea mycelia induces phenotypic and functional differentiation of HL60 into monocyte-like cells via an ERK/CEBP-[beta] signaling pathway

This finding may help the designing of new protocols for T-ALL differentiation therapy in the future.

Bryostatin-1, fenretinide and 1[alpha],25 [(OH).sub.2][D.sub.3] induce growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6)

Differentiation therapy for myelodysplastic syndrome.

A novel approach to treatment in childhood acute myeloblastic leukemia and myelodysplastic syndrome with high-dose methylprednisolone as a differentiation- and apoptosis-inducing agent of myeloid leukemic cells

Thus the dramatic finding that ATRA therapy was successful in APL was the first example of differentiation therapy in the treatment of advanced cancer.

Acute promyelocytic leukaemia, all-trans-retinoic acid and arsenic

Differentiation therapy slows tumor growth and invasion, encouraging tumor cell death through the normal process of programmed cell death (apoptosis).

Glial tumors--new approaches in chemotherapy. (Pharmacology Update)

Differentiation therapy is based on the concept that immature leukemia progenitor cells can be forced to differentiate into a more mature or terminally differentiated phenotype by using differentiation-inducing agents.

Acute promyelocytic leukemia and differentiation therapy: molecular mechanisms of differentiation, retinoic acid resistance and novel treatments/Akut promiyelositik losemi ve diferansiyasyon tedavisi: diferansiyasyonun, retinoik asit direncinin ve yeni tedavilerin molekuler mekanizmalari

Regarding these progresses, differentiation therapy is also considered for treatment of other AML patients.

3-Hydrogenkwadaphnine, a novel diterpene ester from Dendrostellera lessertii, its role in differentiation and apoptosis of KG1 cells

This transformation, called differentiation therapy, reactivates endogenous cellular programs to elicit tumor cell maturation and the transition from cancer to normal tissue.

Auron and Elucidata Forge Scientific Collaboration to Identify and Validate Targets for Differentiation-Based Therapies in Oncology

Lai is the differentiation therapy. He says: The disease could be prevented or cured discerning the occurrence of kinds of normal cells & cancer cells, how cancer cells differ from their normal counterparts, and what events prompts the proliferation of these abnormal cells.

Unraveling the Mystery of Cause & Cure of Cancer by Dr. Shaoqing Lai from Oasis Publishers

One of these ways is the differentiation therapy. It is based on the induction of leukemic blasts to mature beyond the differentiation block and, thus, to restore the normal cellular phenotype.

Nrf2 Expression in CML and AML Patients' Peripheral Blood Mononuclear Cells Treated by Vitamin D, Carnosic Acid and Curcumin

Daniel et al., "All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia.

Prevention and reversal of diabetes by all-trans retinoid acid and exendin-4 in NOD mice