differentiating agent


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differentiating agent

A medication such as all-trans-retinoic acid, used in differentiation therapy.
See also: agent
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
The application of morphoproteomics, in its most complete sense, involves the immunohistochemical assessment of the activation of metabolic pathways in cancer cells, and actually, in any diseased cells, to predict susceptibility to small-molecule inhibitors, specific chemotherapeutic agents, and possibly, differentiating agents. What is the morphologic component of that?
The list includes the following examples: cetuximab to the EGFR ectodomain; tyrosine (Tyr) kinase inhibitors, like gefitinib and erlotinib; imatinib mesylate; the proteasome and NF-[kappa]B pathway inhibitor, bortezomib; rapalogs (temsirolimus, sirolimus), as mTOR pathway inhibitors; histone deacetylase (HDAC) inhibitors, as differentiating agents for tumor-initiating stem cells and as antiangiogenic agents; and so forth.
have entered a collaborative agreement on the development of chemical compounds that hold promise as cell differentiating agents for the possible treatment or prevention of cancer.

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