difenoxin

difenoxin

 [di″fĕ-nok´sin]
an agent used as the hydrochloride salt for its antiperistaltic action in treatment of diarrhea.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
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Compound Lowest 1/1000th Lowest ADE (mg/day) Therapeutic LCD Reported based on LOAEL Dose Teratogenic for Dose Teratogenicity Difenoxin HCL 1 mg 0.001 mg No NA teratogenic effects at up to 61 x therapeutic dose Coumadin 1 mg 0.001 mg 4 1.9 Diethylstilbestrol 1 mg 0.001 mg 0.006 0.003 Ribvirin 600 mg 0.6 mg 0.12 0.06 So to summarize this point, unless the health-based limits are obtained, it is unclear if the limits used are over- or under-protective of patient health.
Risk-MaPP and multi-use facilities: managing cross-contamination risks
The antidiarrheal agents diphenoxylate and its active metabolite, difenoxin, are meperidine-related narcotics.
GI agents: part I

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