diethylstilbestrol


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diethylstilbestrol

 (DES) [di-eth″il-stil-bes´trol]
a synthetic nonsteroidal estrogen used for palliative treatment of prostatic carcinoma and sometimes advanced breast carcinoma. It was formerly used to relieve vasomotor symptoms associated with menopause, and in primary ovarian failure, female hypogonadism, atrophic vaginitis, kraurosis vulvae, and female castration. Most significantly, however, it was formerly widely used to prevent threatened abortion and premature labor. The female children who were thus exposed to the drug as fetuses have tended to have a variety of cervical abnormalities and an increased risk of clear cell adenocarcinoma of the reproductive tract. Male offspring have sometimes had abnormal genitalia, epididymal cysts, and abnormal semen analyses. Regular examinations and follow-up are indicated for these individuals.

di·eth·yl·stil·bes·trol (DES),

(dī-eth'il-stil-bes'trol), Avoid the misspelling/mispronunciation diethylstilbesterol.
A synthetic nonsteroidal estrogenic compound. Sometimes used as a postcoital antipregnancy agent to prevent implantation of the fertilized ovum. The first demonstrated transplacental carcinogen responsible for a delayed clear cell vaginal carcinoma in female offspring of mothers who took the drug during pregnancy when the drug was erroneously thought to prevent threatened abortion.
Synonym(s): stilbestrol

diethylstilbestrol

/di·eth·yl·stil·bes·trol/ (DES) (-stil-bes´trol) a synthetic nonsteroidal estrogen, used as the base or the diphosphate salt for the palliative treatment of prostatic carcinoma and sometimes breast carcinoma; it is an epigenetic carcinogen and females exposed to it in utero are subject to increased risk of vaginal and cervical carcinomas.

diethylstilbestrol

(dī-ĕth′əl-stĭl-bĕs′trôl′, -trōl′)
n. Abbr. DES
A nonsteroidal synthetic drug, C18H20O2, having estrogenic properties and used in the treatment of advanced prostate cancer. Before 1971 it was prescribed to prevent miscarriage and to treat menstrual disorders but was found to cause vaginal cancer and other reproductive abnormalities in the daughters of pregnant women so treated.

diethylstilbestrol (DES)

[-stilbes′trol]
a synthetic hormone with estrogenic properties. This agent was used extensively from 1948 to 1971 to decrease miscarriages, but it is now contraindicated because it is known to increase the risk of vaginal clear cell carcinoma in the women exposed to it in utero (i.e., daughters of mothers who used the drug). Also called stilbestrol.

diethylstilbestrol

See DES.

di·eth·yl·stil·bes·trol

(DES) (dī-eth'il-stil-bes'trol)
A synthetic nonsteroidal estrogenic compound; sometimes previously used as a postcoital antipregnancy agent to prevent implantation of the fertilized oocyte. The first demonstrated transplacental carcinogen responsible for a delayed clear-cell vaginal carcinoma in girls born to mothers who took the drug during pregnancy when it was erroneously thought to prevent miscarriage.
Synonym(s): stilboestrol.

Diethylstilbestrol (DES)

This is a synthetic estrogen drug that is used to treat a number of hormonal conditions. However, it causes problems in developing fetuses and should not be taken during pregnancy. From about 1938 to 1971, DES was given to pregnant women because it was thought to prevent miscarriage. Children of women who took the drug during pregnancy are at risk for certain health problems.

di·eth·yl·stil·bes·trol

(DES) (dī-eth'il-stil-bes'trol)
A synthetic nonsteroidal estrogenic compound; formerly used as a postcoital antipregnancy agent to prevent implantation of the fertilized oocyte.
Synonym(s): stilboestrol.

diethylstilbestrol (dīeth´ilstilbes´trôl),

n an estrogenic substance, C18H20O2, that has an estrogenic activity considered to be greater than that of estrone. Useful in treating menopausal symptoms and occasionally used in the therapy of chronic desquamative gingivitis associated with artificial or natural menopause.

diethylstilbestrol

a synthetic nonsteroidal estrogen; abbreviated DES. In cattle used to treat infertility and as a stimulant to weight gain by increasing muscular development. Its use is limited as a weight gain stimulant because of the possible entry of the compound into the human food chain. Excessive, long-term administration causes anal prolapse, abortion, fracture of the pelvis and nymphomaniac behavior. Sometimes used in dogs to treat misalliance and urinary incontinence, but limited by its myelotoxic effects.
References in periodicals archive ?
A case of vaginal clear cell adenocarcinoma complicated with congenital anomalies of the genitourinary tract and metanephric remnant without prenatal diethylstilbestrol exposure.
For more on this topic, see Bell, "The Synthetic Compound Diethylstilbestrol," chaps.
Estrogen receptor-a knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract.
Most of these risks were increased by a factor of more than two, compared with the risks in women of the same age who Were not exposed to diethylstilbestrol (DES), said Dr.
Nor does she blame the inventor, Sir Charles Dodd, a British researcher who published the formula for diethylstilbestrol in 1938 but did not patent it.
In the 1970s diethylstilbestrol (DES), an estrogen prescribed to pregnant women from the 1930s to the '70s to prevent miscarriage, was found to increase the risk of vaginal cancers in the women's daughters.
Both have been linked to high levels of the sex hormone diethylstilbestrol before birth.
Consider the synthetic estrogen called diethylstilbestrol (DES).
The synthetic hormone, diethylstilbestrol (DES) was withdrawn in the 1970s when it was found to be associated with vaginal cancer and fertility disorders among the women who took it.
A New York trial court judge has ruled lead paint manufacturers can be found liable under market share liability based on an opinion that initially used the legal theory in a suit against manufacturers of the drug diethylstilbestrol (DES).
The patient was then started on diethylstilbestrol, 1 mg by mouth, three times a day.
18 Irreversible Effects of Diethylstilbestrol on Reproductive Organs and a Current