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a synthetic nonsteroidal estrogen used for palliative treatment of prostatic carcinoma and sometimes advanced breast carcinoma. It was formerly used to relieve vasomotor symptoms associated with menopause, and in primary ovarian failure, female hypogonadism, atrophic vaginitis, kraurosis vulvae, and female castration. Most significantly, however, it was formerly widely used to prevent threatened abortion and premature labor. The female children who were thus exposed to the drug as fetuses have tended to have a variety of cervical abnormalities and an increased risk of clear cell adenocarcinoma of the reproductive tract. Male offspring have sometimes had abnormal genitalia, epididymal cysts, and abnormal semen analyses. Regular examinations and follow-up are indicated for these individuals.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
di·eth·yl·stil·bes·trol (DES),(dī-eth'il-stil-bes'trol), Avoid the misspelling/mispronunciation diethylstilbesterol.
A synthetic nonsteroidal estrogenic compound. Sometimes used as a postcoital antipregnancy agent to prevent implantation of the fertilized ovum. The first demonstrated transplacental carcinogen responsible for a delayed clear cell vaginal carcinoma in female offspring of mothers who took the drug during pregnancy when the drug was erroneously thought to prevent threatened abortion.
Farlex Partner Medical Dictionary © Farlex 2012
n. Abbr. DES
A nonsteroidal synthetic drug, C18H20O2, having estrogenic properties and used in the treatment of advanced prostate cancer. Before 1971 it was prescribed to prevent miscarriage and to treat menstrual disorders but was found to cause vaginal cancer and other reproductive abnormalities in the daughters of pregnant women so treated.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
A synthetic nonsteroidal estrogenic compound; sometimes previously used as a postcoital antipregnancy agent to prevent implantation of the fertilized oocyte. The first demonstrated transplacental carcinogen responsible for a delayed clear-cell vaginal carcinoma in girls born to mothers who took the drug during pregnancy when it was erroneously thought to prevent miscarriage.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
This is a synthetic estrogen drug that is used to treat a number of hormonal conditions. However, it causes problems in developing fetuses and should not be taken during pregnancy. From about 1938 to 1971, DES was given to pregnant women because it was thought to prevent miscarriage. Children of women who took the drug during pregnancy are at risk for certain health problems.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
A synthetic nonsteroidal estrogenic compound; formerly used as a postcoital antipregnancy agent to prevent implantation of the fertilized oocyte.
Medical Dictionary for the Dental Professions © Farlex 2012