Evaluation of the toxic activity of anorectic diethylpropion
in Chinese hamster ovary cells.
Also in 2000, the European Medicines agency (EMA) recommended the market withdrawal of several anti-obesity drugs, including phentermine, diethylpropion
, and mazindol, due to an unfavorable risk to benefit ratio.
Pharmacological and neurotoxicological actions mediated by bupropion and diethylpropion
. Int Rev Neurobiol 2009; 88: 223-55.
, phendimetrazine, and benzphetamine have remained on the US market, with phentermine being the most prescribed weight loss drug in this class, as well as among all approved antiobesity drugs.
, a sympathomimetic amine similar to amphetamine, is a prodrug metabolized to 2-ethylamino-1-phenyl-propan-1-one and N, N-diethylnorephedrine metabolites , the latter being responsible for its effects.
Central noradrenergic agents (phentermine, diethylpropion
, phendimetrazine, and benzphetamine) have been available since the 1950s.
Centrally acting sympathomimetics, such as the amphetamine derivatives desoxyephedrine, phentermine and diethylpropion
, were among the earliest pharmacological agents used for weight loss.
Primary pulmonary hypertension after amfepramone (diethylpropion
) with BMPR2 mutation.
The same goes for Diethylpropion
, another potentially addictive medication available in the U.S.
Another recommendation is that phentermine and diethylpropion
(Tenuate) should not be used in patients with uncontrolled high blood pressure or a history of heart disease.
The FDA has approved four drugs for short-term use (up to 12 weeks) that suppress appetite: phentermine, benzphetamine, diethylpropion
, and phendimetrazine.
and benzphetamine pass into breast milk.