phosphate

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phosphate

 [fos´fāt]
any salt or ester of phosphoric acid. adj., adj phosphat´ic.

Phosphates are widely distributed in the body, the largest amounts being in the bones and teeth. They are continually excreted in the urine and feces and must be replaced in the diet. Inorganic phosphates function as buffer salts to maintain the acid-base balance in blood, saliva, urine, and other body fluids. The principal phosphates in this buffer system are monosodium and disodium phosphate. Organic phosphates, in particular adenosine triphosphate (ATP), take part in a series of reversible reactions involving phosphoric acid, lactic acid, glycogen, and other substances, which furnish the energy expended in muscle contraction. This is thought to occur through the hydrolysis of the so-called high-energy phosphate bond present in ATP, phosphocreatine, and certain other body compounds.

phos·phate (P),

(fos'fāt),
A salt or ester of phosphoric acid. For individual phosphates not listed here, see under the name of the base.

phos·phate

(fos'fāt)
1. A salt or ester (especially inorganic) of phosphoric acid.
2. The trivalent ion, PO43-.

phosphate

any salt or ester of any PHOSPHORIC ACID.

Phosphate

An organic compound necessary for mineralization of bone and other key cellular processes.
Mentioned in: Hyperparathyroidism
References in periodicals archive ?
In healthy subjects, FGF23 increases after hours of dietary phosphate load; however, a 4-hour intravenous infusion of phosphate does not alter FGF-23 level at 6 hours, whereas chronic phosphate infusion results in an increase in FGF-23 at 24 hours [28-30, 33, 34].
Finkelstein, "Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women," Journal of Bone and Mineral Research, vol.
Neves, "Effects of dietary phosphate on adynamic bone disease in rats with chronic kidney disease--role of sclerostin?" PLoS ONE, vol.
W Coburn, "Intestinal absorption of calcium: role of dietary phosphate and vitamin D," The American Journal of Physiology, vol.
(5) When taken with meals, calcium acetate combines with dietary phosphate to form insoluble calcium phosphate, which is excreted in the feces.
Phytate is one source of dietary phosphate for both humans and animals.
Dicalcium phosphate is most important dietary phosphate source for chicken that can supply more than 85percent of inorganic phosphorus requirements [4].
Management of hyperphosphatemia consists of dietary phosphate restriction, medications and dialysis.
In athletes, such a state is most often caused by incomplete recovery from training and competition, or dietary phosphate deficiency.
However, in many patients with CKD or ESRD, and patients on maintenance dialysis, the administration of phosphate binding medications are almost always required to limit the absorption of dietary phosphate in the GIT (Cronin, Berns & Post, 2009).
Since excess phosphate has been shown to stimulate a metabolic pathway associated with lung cancer promotion, Korean researchers investigated the effects of excess dietary phosphate on lab mice bred to model human lung cancer.
Fosrenol(R) is a non-aluminium, non calcium phosphate binder that has a very high affinity for dietary phosphate, forming lanthanum phosphate, which passes through the intestines and is eliminated from the body, leading to effective reduction in serum phosphorus levels.

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