dideoxynucleoside

dideoxynucleoside

 [-noo´kle-o-sīd]
any of a group of synthetic nucleoside analogues, several of which are used as antiretroviral agents.

dideoxynucleoside

/di·de·oxy·nu·cleo·side/ (-noo´kle-o-sīd) any of a group of synthetic nucleoside analogues, several of which are used as antiretroviral agents.

dideoxynucleoside

AIDS Any of a family of compounds eg, zidovudine, didanosine, and zalcitabine used to treat HIV-positive Pts. See ddC, Didanosine.
References in periodicals archive ?
4) Since the introduction of dideoxynucleoside reverse transcriptase inhibitors (NRTIs) in 1985 and after the approval of the first protease inhibitor in 1995, the availability of new fixed-dose combinations regimens of new antiretroviral drugs, evolved faster in the developed world.
The PC12 cell as a model for studies of the mechanism of inducing of peripheral neuropathy by anti-HIV-l dideoxynucleoside analogs.
In vitro models to predict the in vivo mechanism, rate and extet of placental transfer of dideoxynucleoside drugs against human immunodeficiency virus.
Lamivudine (3TC), the negative enantiomer of 2'-deoxy-3'thiacytidine, is a dideoxynucleoside analogue used in combination with other agents in the treatment of human immunodeficiency virus type 1 (HIV-1) infection and as monotherapy in the treatment of hepatitis B virus (HBV) infection.
Assay-specific deoxynucleoside triphosphates (dATP, dGTP, dTTP; Amersham) and dideoxynucleoside triphosphates (ddA, ddC, ddG, ddT; BioLog Life Science Institute) were added at 0.
Therefore, in that study, a very short extension strategy using alternating deoxynucleoside triphosphates (dNTPs) and dideoxynucleoside triphosphates was adopted so that the products differed in mass by [M.
75 [micro]M primer, 25 [micro]M each of the dideoxynucleoside triphosphates (Amersham Pharmacia Biotech), and 0.
Our strategy for detecting the splice variants expressed from the genes is based on the extension of gene-specific minisequencing primers with fluorescent dideoxynucleoside triphosphates (ddNTPs), each of which define a specific splice variant (see Table 52 in the online Data Supplement).
1) Nonstandard abbreviations: HAEC, human aortic endothelial cell; HUVEC, human umbIIical vein endothelial cell; dNTP, deoxynucleoside triphosphate; ddNTP, dideoxynucleoside triphosphate; Ct, threshold cycle; s/n, signal-to-noise rafio; and s/i, signal iracfion.
DNA polymerase extends it by adding one fluorescently labeled dideoxynucleoside triphosphate complementary to the variant base.
Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.
Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides.