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a nucleoside analogueantiretroviral agent used for the treatment of advanced human immunodeficiency virus infection and acquired immunodeficiency syndrome; administered orally.


/di·de·oxy·in·o·sine/ (-in´o-sēn) didanosine.


(dī′dē-ŏk′sē-ĭn′ə-sēn′, -sĭn, -ī′nə-)

dideoxyinosine (ddI)

an antiretroviral drug used in the treatment of human immunodeficiency virus infections. ddI inhibits the enzyme reverse transcriptase, thereby restricting viral replication activity. Inside the body, ddI is converted to dideoxyadenosine, which becomes incorporated into the deoxyribonucleic acid chain, interrupting its normal sequence and making viral replication impossible. Also called didanosine.
References in periodicals archive ?
Indications for Changing a Patient from Zidovudine (AZT) to Dideoxyinosine (ddI) or Dideoxycytidine (ddC) Severe AZT side effects(*) Decrease in hemoglobin at a rate of >2 g/month Absolute neutrophil count [<750/mm.
A genetically engineered compound called soluble CD4 slowed the progression of AIDS (137: 101), while the drug dideoxyinosine sparked concerns about serious side effects (137: 315).
The two most recent tests of the experimental AIDS drug dideoxyinosine (DDI) have provided a more revealing peek at a potentially powerful weapon against AIDS.