Dideoxyinosine | definition of dideoxyinosine by Medical dictionary
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Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
dideoxyinosine (dī′dē-ŏk′sē-ĭn′ə-sēn′, -sĭn, -ī′nə-)
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive
Indications for Changing a Patient from Zidovudine (AZT) to Dideoxyinosine
(ddI) or Dideoxycytidine (ddC) Severe AZT side effects(*) Decrease in hemoglobin at a rate of >2 g/month Absolute neutrophil count [<750/mm.sup.3] Vomiting or intractable nausea Severe headaches uncontrolled with analgesics Acute psychosis Severe agitation Declining muscle strength associated with creatine phosphokinase >100 U/mL AZT failure Significant, involuntary weight loss (>10 lb) Neurological deterioration (dementia, transverse myelitis) Three or more opportunistic infections CD4+ count [<50/mm.sup.3] Karnofsky score [is less than or equal to 40]+ Concomitant use of gancylovir (*) Need to recur with AZT rechallenge.
A genetically engineered compound called soluble CD4 slowed the progression of AIDS (137: 101), while the drug dideoxyinosine
sparked concerns about serious side effects (137: 315).
The two most recent tests of the experimental AIDS drug dideoxyinosine
(DDI) have provided a more revealing peek at a potentially powerful weapon against AIDS.