dideoxycytidine


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Related to dideoxycytidine: zalcitabine

dideoxycytidine

 [-si´tĭ-dēn]
an antiretroviral agent whose base is cytosine; it acts by inhibiting reverse transcriptase and is used in treating human immunodeficiency virus infection and aids.
References in periodicals archive ?
Indications for Changing a Patient from Zidovudine (AZT) to Dideoxyinosine (ddI) or Dideoxycytidine (ddC) Severe AZT side effects(*) Decrease in hemoglobin at a rate of >2 g/month Absolute neutrophil count [<750/mm.sup.3] Vomiting or intractable nausea Severe headaches uncontrolled with analgesics Acute psychosis Severe agitation Declining muscle strength associated with creatine phosphokinase >100 U/mL AZT failure Significant, involuntary weight loss (>10 lb) Neurological deterioration (dementia, transverse myelitis) Three or more opportunistic infections CD4+ count [<50/mm.sup.3] Karnofsky score [is less than or equal to 40]+ Concomitant use of gancylovir (*) Need to recur with AZT rechallenge.
Examples: AZT, foscarnet, dideoxycytidine, dextran sulfate
The doctor will probably prescribe medicine, such as AZT (now called ZDV, for zidovudine), didanosine (ddI), or dideoxycytidine (ddC) to help slow your child's HIV infection.
The drug zalcitabine--also known as dideoxycytidine (DDC) --last week became the third drug approved by the Food and Drug Administration for combating infection with HIV, the virus that causes AIDS.
The drug, dideoxycytidine (DDC), would be used in combination with zidovudine (AZT), the first antirival AIDS drug approved by the agency.