dicumarol


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dicumarol

 [di-koo´mah-rol]
a coumarinanticoagulant that acts by inhibiting the synthesis of vitamin K–dependent coagulation factors (prothrombin and factors VII, IX, and X) and proteins C and S in the liver; used in the prevention and treatment of thromboembolic disorders.

di·cu·ma·rol

(dī-kū'mă-rol),
An anticoagulant that acts in the liver to block synthesis of vitamin K and vitamin K-dependent coagulation factors; discovered as the causative agent in spoiled hay, which caused bleeding in cattle (sweet clover disease).
See also: warfarin.

di·cu·ma·rol

(dī-kū'mă-rol)
An anticoagulant that acts in the liver to block synthesis of vitamin K and vitamin K-dependent coagulation factors; discovered as the causative agent in spoiled hay, which caused bleeding in cattle (sweet clover disease).
See also: warfarin
References in periodicals archive ?
K, pero en presencia de dicumarol, este inhibe la reductasa y por ende su reduccion.
If you have a mechanical valve (made of metal or plastic with a moving ball or disc), and it's necessary for you to take blood-thinning medicines such as Coumadin or Dicumarol to prevent blood clots from forming on the valve, this medicine can cause damage to your baby.
Caffeic acid, ferulic acid, DMSO, and assay substrates (dihydrodichlorofluorescein, rhodamine 123, nile red, 7-ethoxyresorufin, 7-benzyloxyresorufin, resorufin, H33258, salicylamide, dicumarol) were purchased from Sigma (St.
Then, 7-ethoxyresorufin (2 [micro]M, Sigma-Aldrich Chemie GmbH, Deisenhofen, Germany; dissolved in DMSO) and dicumarol (10 [micro]M; Sigma-Aldrich Chemie GmbH) were added, and cells were incubated at 37[degrees]C for 4 hr and centrifuged for 5 min (1,200 x g, 4[degrees]C).
Unusual hemorrhagic complications in dicumarol therapy.
The control of dicumarol therapy and the quantitative determination of prothrombin and proconvertin.
In a 96-well Microlite-1 plate (Dynex, Chantilly, VA), we mixed 30 [micro]L cell homogenates with 100 [micro]L 50 mM HEPES buffer, pH 7.8, containing 40 [micro]M dicumarol, and 50 [micro]L of a 20 [micro]M stock solution of ethoxyresorufin with 1.25% Tween 80.