The Company's rare neuromuscular franchise includes KEVEYIS (
dichlorphenamide), the first and only FDA-approved treatment for hyperkalemic, hypokalemic, and related variants of primary periodic paralysis.
In the treatment of different diseases such as obesity, cancer and glaucoma, CA inhibitors are emerging to be used as remedy [26].Glaucoma is treated by the drugs such as
dichlorphenamide, methazolamide, and acetazolamide which target the enzyme carbonic anhydrase [25].
The agenda will include an overview of the market opportunity and commercial strategy for KEVEYIS (
dichlorphenamide) for the treatment of PPP, and MACRILEN (macimorelin) for the diagnosis of AGHD.
CAI research led to the development of first generation CAIs that are still available in the clinic, including acetazolamide (Diamox), methazolamide (Neptazane), ethoxzolamide, and
dichlorphenamide (Keveyis).
(2,4,6) Mechanism Drug Class Preparations of Action Reduction Adrenergic Brimonidine of Aqueous agonists Apraclonidine Inflow [beta]-blockers Non-selective Timolol Levobunolol Carteolol Selective [beta]-blockers Betaxolol Carbonic Systemic anhydrase Acetazolamide inhibitors Methazolamide
Dichlorphenamide Topical Dorzolamide Brinzolamide Increase Cholinergics Pilocarpine in Aqueous Increase Carbachol Outflow trabecular outflow Prostaglandins Latanoprost (xalatan) and other lipid Travoprost (travatan) receptor agonists Increase Bimatoprost (lumigan) uveoscleral Unoprostone outflow Table 2: The Demographic Data of the Patients of POAG Selected for the Study Bimatoprost Timolol Maleate No.
Additionally, acetazolamide,
dichlorphenamide, and carbonic anhydrase inhibitors are not generally recommended for the preventive treatment of migraines but maybe effective for the prevention of VM [82].
Pharmaceutical company Taro Pharmaceutical Industries (NYSE:TARO) disclosed on Monday the launch of Keveyis (
dichlorphenamide) 50 mg Tablets for the treatment of primary hyperkalemic and hypokalemic periodic paralysis and related variants in the US market.
(9)
Dichlorphenamide was administered orally to 2 raptors with suspected glaucoma at the dose rate used in dogs and buphthalmos resolved in one case.
These include acetazolamide (Diamox),
dichlorphenamide (Daranide) and methazolamide (Neptazane).
--Potential Treatments: Medical treatment: administration of autonomic agents (pilocarpine, epinephrine, dipivefrin, or timolol), diuretics (mannitol), carbonic anhydrase inhibitors (
dichlorphenamide), and prostaglandin analogs (latanoprost).
Miscellaneous medications: clofibrate,
dichlorphenamide, fenfluramine, ketoconazole, methadone, methazolamide, norethindrone, thiabendazole
'We are encouraged by the quarter-over-quarter revenue growth achieved with KEVEYIS (
dichlorphenamide) during the second quarter of 2019.
