At the time of evaluation with the headache clinic, she was on topiramate, magnesium, combination of isometheptene mucate, dichloralphenazone
, and acetaminophen and as needed oxycodone, which she used 2-3 tablets per week.
A multicenter, double-blind, randomized parallel group study (8) showed no difference between the combination product isometheptene mucate, dichloralphenazone with acetaminophen (Midrin, Duradrin, etc) (used as recommended in the package insert with a maximum of up to 5 tablets within 24 hours) vs oral sumatriptan (initial dose of 25 mg with a repeat 25 mg dose in 2 hours).
Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine.
Since March, 2002, Esclim(TM) (estradiol transdermal system), ORTHO-EST(R) Tablets (estropipate), and Midrin(R) (isomethepene mucate, USP, dichloralphenazone, USP and acetaminophen, USP), have been on Express Scripts' recommended formularies.
Midrin(R) (isometheptene mucate, USP, dichloralphenazone, USP and acetaminophen, USP) is indicated for relief of tension and vascular headaches.
Treatment of migraine with isometheptene, acetaminophen, and dichloralphenazone
combination: a double-blind, crossover trial.
6% of patients), Midrin (isometheptene, dichloralphenazone
, acetaminophen; 23.