dibucaine number


Also found in: Acronyms.

di·bu·caine num·ber (DN),

(dib'yū-kān nŭm'bĕr),
A test for differentiation of one of several forms of atypical pseudocholinesterases that are unable to inactivate succinylcholine at normal rates; based on the percentage of inhibition of the enzymes by dibucaine, normal enzyme has a DN of at least 75 and higher, heterozygous atypical enzyme has a DN of 40-70, and homozygous atypical enzyme has a DN of less than 20.
See also: fluoride number.
References in periodicals archive ?
A method for the detection of atypical forms of human serum cholinesterase; determination of dibucaine numbers. Can J Biochem Physiol 1957;35:339-46.
(4) Nonstandard abbreviations: BCHE, butyrylcholine esterase; DN, dibucaine number; FN, fluoride number; SSCP, single-strand conformation polymorphism; and RFLP, restriction fragment length polymorphism.