The next level of drugs is represented by the diamidines, namely propamidine and dibromopropamidine. These are also available to all optometrists and are chemical agents (ie, anti-infectives not antibiotics) best described as general-purpose bacteriostatic agents.
For eye drops containing dibromopropamidine, no pharmacokinetic data appear to have been published.
Similar effects would be expected for dibromopropamidine or polymyxin B and bacitracin eye ointments.
The two drug options available in the UK are propamidine, in the form of P Brolene and P Golden Eye eye drops, and dibromopropamidine, in the form of P Brolene eye ointment and P Golden Eye ointment.