dibenzodiazepine

dibenzodiazepine

 
any of a class of structurally related heterocyclic drugs including the antipsychotic agentclozapine.
References in periodicals archive ?
Clozapine is an FDA approved first atypical antipsychotic which is the only dibenzodiazepine available in the US (Li and Corey, 2013; Yagiela et al., 2010).
Clozapine, the gold standard for refractory schizophrenia, is a dibenzodiazepine and lowers D2 receptor occupancy and is also a 5-hydroxytryptamine antagonist.
Other example is diazepinomicin, a dibenzodiazepine alkaloid with antimicrobial properties isolated from a Micromonospora strain recovered from Didemnum proliferum, a tunicate collected off the Japanese coast (Charan et al., 2004).
The introduction of dibenzodiazepine antipsychotic agent, clozapine, is an important development in the pharmacotherapy of schizophrenia.
Clozapine is a dibenzodiazepine. Its black-box warning states, "Since collapse, respiratory arrest, and cardiac arrest during initial treatment has occurred in patients who were being administered benzodiazepines or other psychotropic drugs, caution is advised when clozapine is initiated in patients taking a benzodiazepine or any other psychotropic drug." (3)
What not everyone knows is that loxapine is a member of the dibenzoxazepine class of medication, and it is structurally related to clozapine, which belongs to a class of medication known as dibenzodiazepines --a class that is extraordinarily similar to dibenzoxazepine.