A purified human hemoglobin derivative that binds oxygen; has the potential to reduce the need for red blood cell transfusion in patients undergoing surgery.
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Clinical trials have been halted on a diaspirin cross-linked tetrameric hemoglobin (DCLHemoglobin[R]; Baxter Healthcare), but a tetrameric human hemoglobin comprising two stable [alpha]-[beta]subunits derived from genetically engineered Escherichia coli is currently under development.
Our investigations into the interference effects of diaspirin cross-linked hemoglobin chains (DCLHb; also known as HemAssist[R]; Baxter Healthcare Corp., Deerfield, IL) on laboratory testing methods using the method of Kroll et al.
Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion.
Evaluation of two solid-phase adsorbents for the selective removal of diaspirin cross-linked hemoglobin (DCLHb[R]) from clinical samples [Abstract].
Modification of clinical chemistry methods to overcome interferences from diaspirin cross-linked hemoglobin (DCLHb) [Abstract].