diaminopyrimidinesDrugs used to treat or prevent MALARIA. Examples are pyrimethamine (Daraprim) and sulphadoxine with pyrimethamine (Fansidar).
synthetic antimicrobial agents that act as competitive antagonists in the conversion of folic acid to folinic acid. Examples are trimethoprim and pyrimethamine. Usually combined with a sulfonamide, providing a sequential blockade in nucleic acid synthesis.