diaminopyrimidines

diaminopyrimidines

Drugs used to treat or prevent MALARIA. Examples are pyrimethamine (Daraprim) and sulphadoxine with pyrimethamine (Fansidar).

diaminopyrimidines

synthetic antimicrobial agents that act as competitive antagonists in the conversion of folic acid to folinic acid. Examples are trimethoprim and pyrimethamine. Usually combined with a sulfonamide, providing a sequential blockade in nucleic acid synthesis.
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These drugs were administered alone from the 1930s through the 1960s in humans and were almost exclusively combined with diaminopyrimidines (e.
B-817: A novel staphylococcal murine preclinical model of infection was established for diaminopyrimidines.
The next describes classes of agents and includes chapters on beta-lactam antibiotics; peptide antibiotics; lincosamides, pleuromutilins, and streptogramins; macrolides, azalides, and ketolides; aminoglycosides; tetracyclines and glycylcyclines; chloramphenicol, thiamphenicol, and florfenicol; sulfomanides, diaminopyrimidines, and their combinations; fluorquinolones; antifungal chemotherapy agents; and antiviral chemotherapy agents.