diamine oxidase


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a·mine ox·i·dase

1. an oxidoreductase containing copper, and perhaps pyridoxal phosphate, and carrying out the same reaction as amine oxidase (flavin-containing). Synonym(s): diamine oxidase, histaminase
2. an oxidoreductase containing flavin and oxidizing amines with the aid of O2 and water to aldehydes or ketones with the release of NH3 and H2O2. Acted upon by antidepressants. Synonym(s): adrenaline oxidase, monoamine oxidase, tyraminase, tyramine oxidase

diamine oxidase

Amine oxidase (copper-containing), EC 1.4.3.6. This enzyme was deleted as it was classified based on cofactor content rather than reaction catalysed; it is now known to contain two distinct enzyme activities, and thus has been replaced by two enzymes: EC 1.4.3.21 (primary-amine oxidase) and EC 1.4.3.22 (diamine oxidase).
References in periodicals archive ?
Changes of inflammatory mediators and diamine oxidase
Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats.
Human intestinal diamine oxidase: substrate specificity and comparative inhibitor study.
The importance of human intestinal diamine oxidase in the oxidation of histamine and/or putrescine.
Biochemical, physiological and pathophysiological aspects of intestinal diamine oxidase. Acta Physiol Pol 1983; 34: 139-54.
Diamine oxidase polymorphisms have been associated with inflammatory intestinal diseases, including food allergies, whereas low enzyme activity caused by HNMT polymorphisms has been associated with asthma (Maintz L.
When there is an overgrowth of harmful organisms, the intestinal microvilli that make diamine oxidase are compromised, affecting histamine degradation and causing us to be more sensitive to histamine.
Plasma diamine oxidase activity is a useful biomarker for evaluating gastrointestinal tract toxicities during chemotherapy with oral fluorouracil anti-cancer drugs in patients with gastric cancer.
Purification and characterization of diamine oxidase from clover leaves.
Amperometric biosensor for diamine using diamine oxidase purified from porcine kidney.
Effects of Arg supplementation on plasma d/xylose content (mmol/L), and intestinal mucosal diamine oxidase (DAO) activity (U/mg protein) of weaned pigs after 6 h Escherichia coli LPS challenge (1) Item Plasma d-xylose CONTR LPS LPS+0.5% Arg DAO 0.178 (b) 0.096 (a) 0.108 (a) Duodenum 0.175 (a) 0.153 (a) 0.323 (b) Jejunum 0.220 0.244 0.288 Ileum 0.311 (b) 0.172 (a) 0.307 (b) Item Plasma d-xylose LPS+1.0% Arg SEM Orthogonal contrast (2) DAO 0.108 (a) 0.032 0.562 Duodenum 0.156 (a) 0.024 0.001 Jejunum 0.246 0.079 0.641 Ileum 0.278 (b) 0.047 0.005 SEM = Standard error of the mean.