diabetic polyneuropathy


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di·a·bet·ic pol·y·neu·rop·a·thy

a distal, symmetric, generally sensorimotor polyneuropathy that is a frequent complication of diabetes mellitus.

polyneuropathy

(pol?e-noo-rop'a-the) [ poly- + neuropathy]
Any disease that affects multiple peripheral nerves.

acute inflammatory demyelinating polyneuropathy

Guillain-Barré syndrome.

acute inflammatory polyneuropathy

Guillain-Barré syndrome.

amyloid polyneuropathy

Polyneuropathy characterized by deposition of amyloid in nerves.

chronic inflammatory demyelinating polyneuropathy

Abbreviation: CIDP
A gradually progressing autoimmune muscle weakness in arms and legs caused by inflammation of the myelin sheath covering peripheral nerve axons. Demyelination slows or blocks conduction of impulses to muscles. Numbness and paresthesia may accompany or precede loss of motor function, which varies from mild to severe. Laboratory findings include elevated protein levels in the cerebrospinal fluid. The inflammatory damage involves not only phagocytes (neutrophils and macrophages), but also immune complexes and complement activation by myelin autoantigens. Immunosuppressive drugs are used to treat this illness. Plasma exchange therapy or infusions of immunoglobulins often are used first, to produce a remission. CIDP is considered to be a chronic counterpart to Guillain-Barré syndrome.

critical illness polyneuropathy

Abbreviation: CIP
A complication occurring in patients in intensive care in which failure to wean from mechanical ventilation is associated with distal limb weakness, loss of distal sensation from light touch or pinprick, and diminished reflexes; facial muscles and nerves are spared. Recovery typically occurs several weeks or months after resolution of the underlying disease. It is associated with the use of drugs, such as corticosteroids or paralytic agents, and neurological illnesses, such as Guillain-Barre syndrome.

diabetic polyneuropathy

Diabetic neuropathy.

familial amyloiditic polyneuropathy

An inherited form of amyloid polyneuropathy in which abnormal forms of transthyretin are deposited in nerves and brain tissue, making multiple nerves malfunction.

paraproteinemic polyneuropathy

Polyneuropathy due to excessive levels of immunoglobulin in the blood. The most commonly implicated immunoglobulins are IgM and IgG.

porphyric polyneuropathy

Polyneuropathy due to acute porphyria, characterized by pains and paresthesias in the extremities and by flaccid paralysis.

progressive hypertrophic polyneuropathy

Déjérine-Sottas disease.
References in periodicals archive ?
Lipoic acid or thioctic acid (LA) is an octanoic acid derivative that has been used for symptomatic relief in diabetic polyneuropathy with positive results.
Malek et al., "Rapid screening of diabetic polyneuropathy: selection of accurate symptoms and signs in an outpatient clinical setting," Acta Medica Iranica, vol.
Litchy et al., "Efficacy and safety of antioxidant treatment with [alpha]-lipoic acid over 4 years in diabetic polyneuropathy. The NATHAN 1 trial," Diabetes Care, vol.
The involvement of these chronic hyperglycemia mediated metabolic aberrances has also been proven in diabetic polyneuropathy (DPN) [16, 17].
Thus, some authors [31] investigated whether circulating concentrations of acute-phase proteins, cytokines, and chemokines differ among diabetic patients with or without diabetic polyneuropathy. They measured 10 markers of subclinical inflammation in 227 type 2 diabetic patients with diabetic polyneuropathy who participated in the population-based MONICA/KORA Survey F3.
Moreover, several studies demonstrated the efficacy of 600 or more mg of Alpha-lipoic acid administered for few weeks or months [30, 31] in the treatment of diabetic polyneuropathy.
Ziegler et al., "Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)," Diabetes Care, vol.
Lack of physical activity and a sedentary life style among South Asians has been recognized as a risk factor for developing diabetes.3 Diabetic polyneuropathy is an important and sometimes disabling complication of long standing diabetes.
Might genetics play a role in understanding and treating diabetic polyneuropathy? Diabetes Metab Res Rev 2017; 33(4): e2882.
Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials.
Diabetic polyneuropathy is associated with respiratory muscle impairment in Type 2 diabetes.
Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis.