diabetic glomerulosclerosis

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Related to diabetic glomerulosclerosis: amyloidosis


diabetic glomerulosclerosis (intercapillary glomerulosclerosis) a degenerative complication of diabetes mellitus in which there is glomerular mesangial expansion with either diffuse lesions or nodular (Kimmelstiel-Wilson) lesions; symptoms include albuminuria, nephrotic edema, hypertension, renal insufficiency, and retinopathy. The type with nodular lesions is also called Kimmelstiel-Wilson syndrome.
focal segmental glomerulosclerosis focal sclerosing lesions of the renal glomeruli, with proteinuria, hematuria, hypertension, and the nephrotic syndrome; it may be idiopathic or secondary to another condition. Called also focal glomerular sclerosis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

di·a·bet·ic glo·mer·u·lo·scle·ro·sis

proteinuria and ultimately, renal failure occuring in long-standing diabetes, and characterized by rounded hyaline or laminated nodules in the periphery of the glomeruli with capillary basement membrane thickening, and increased mesangial matrix.Synonym(s): intercapillary glomerulosclerosis
Farlex Partner Medical Dictionary © Farlex 2012

di·a·bet·ic glo·mer·u·lo·scler·o·sis

(dī-ă-bet'ik glŏ-mer'yū-lō-skler-ō'sis)
Rounded hyaline or laminated nodules in the periphery of the glomeruli with capillary basement membrane thickening and increased mesangial matrix occurring in long-standing diabetes, proteinuria, and ultimately renal failure.
Synonym(s): intercapillary glomerulosclerosis.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

diabetic glomerulosclerosis

A type of glomerulosclerosis seen in some cases of diabetes mellitus. Eosinophilic material is present in various parts of the glomerulus.
Synonym: intercapillary glomerulosclerosis
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Nodular diabetic glomerulosclerosis has a variety of pathological features but still should be differentiated from another mesangial nodular sclerosing glomerulopathy, which usually has similar light microscopic manifestations.
IV Advanced diabetic glomerulosclerosis in >50% of glomeruli.
Diabetic glomerulosclerosis (DGS) was diagnosed by the presence of mesangial expansion, with or without thenodular Kimmelstiel--Wilson (KW) formation, basement membrane thickening, fibrin caps, or capsular drops.
The biopsy findings include Post-streptococcal glomerulonephritis super imposing on Diabetic glomerulosclerosis, Acute tubulointerstitial nephritis superimposing on Diabetic glomerulosclerosis & chronic interstitial nephritis, HIVAN superimposing on Diabetic glomerulosclerosis.
Idiopathic nodular glomerulosclerosis is a condition that resembles nodular diabetic glomerulosclerosis but occurs in nondiabetic patients with a history of smoking, hypertension, hypercholesterolemia, and extrarenal vascular disease.
Diffuse diabetic glomerulosclerosis and Kimmelstiel-Wilson nodules (nodular glomerulosclerosis) are seen only later in the disease, although the latter is not always seen on biopsy as is classically taught [20].
(15) This early description of the glomerular tip lesion was not restricted to FSGS, but rather a novel report of a curious glomerular abnormality seen independently in patients with proteinuria as well as being found in other heterogeneous renal abnormalities with associated proteinuria, including membranous glomerulopathy and diabetic glomerulosclerosis.
Taguchi, "Identification of type VI collagen synthesizing cells in human diabetic glomerulosclerosis using renal biopsy sections," Analytical Cellular Pathology, vol.